Resinoid of Liquidambar styraciflua (Hamamelidaceae) obtained from exudate by organic solvents extraction

Melting point / freezing point

Link to relevant study record(s)

Reference

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Experimental phase: December 2017.

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Remarks:

The study was conducted according to an internationally recognised method, with no deviation. The substance is considered to be adequately characterised. Therefore full validation applies.

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Version / remarks:

July 27, 1995

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

Version / remarks:

Regulation (EC) n°440/2008

Deviations:

no

GLP compliance:

no

Type of method:

differential scanning calorimetry

Specific details on test material used for the study:

Storage Conditions: Ambient temperature in a dark place, in the original glass bottle.

Key result

Melting / freezing pt.:

ca. -79.4 °C

Melting / freezing pt.:

ca. -80 - ca. -40 °C

A single endothermic signal was recorded for the transition.

The peak profiles are a little spread, this may be due to the UVCB nature of the substance.

As an UVCB, a range is stated; however, given the classical peak profile, the onset value was also retained as representative. It should nevertheless be noted that this result may vary slightly with the substance composition.

	Range of thermal event	Assay 1	Assay 2	Mean (+/- Standard Deviation)
Melting point (°C)	ca -80 to -40°C	-79.48	-79.39	-79.43 +/- 0.1

The duplicate determinations are within the estimated accuracy of +/-0.5°C (according to the guidelines), therefore no additional measurement is required, and the average result is retained.

Executive summary:

The melting point of the test substance was determined according to OECD 102/EU A1 guidelines, DSC method.

Two runs were performed: a single endothermic peak was recorded for the melting transition, covering a wide temperature range between ca -80 and -40°C. This is consistent with the UVCB nature of the substance. Onset values were repeatable, so the mean result was retained as a representative value.

The melting temperature of test substance has been determined to be ca -79.4°C.

Description of key information

Melting (i.e. solid-liquid transition) occurs between -80 and -40°C, with a representative value at onset ca -79.4°C.

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:

-79.4 °C

Additional information

A fully reliable experimental study, conducted according to a recognized OECD method, is available. Therefore it is considered as a key study, and the result is retained as key data.