Registration Dossier
Registration Dossier
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EC number: 249-648-8 | CAS number: 29461-13-0
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer reviewed journal.
Data source
Reference
- Reference Type:
- publication
- Title:
- Fragrance report of test chemical
- Author:
- D.L.J. Opdyke
- Year:
- 1 979
- Bibliographic source:
- Food and Cosmetics Toxicology 1979
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Skin irritation study of the given test chemical was conducted on human subjects to determine the degree of skin irritancy caused by the chemical under occlusive condition.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3,3-dimethyl-8,9-dinorbornan-2-one
- EC Number:
- 214-804-6
- EC Name:
- 3,3-dimethyl-8,9-dinorbornan-2-one
- Cas Number:
- 1195-79-5
- Molecular formula:
- C10H16O
- IUPAC Name:
- 3,3-Dimethyl-8,9-dinorbornan-2-one
- Test material form:
- liquid
- Details on test material:
- - Name of test material : 3, 3-Dimethyl-8, 9-dinorbornan-2-one
- Common name : 1,3,3-trimethylbicyclo[2.2.1]heptan-2-one
- Molecular formula : C10H16O
- Molecular weight : 152.2354 g/mol
- Smiles notation : C[C@@]12CC[C@@H](C1)C(C)(C)C2=O
- InChl : 1S/C10H16O/c1-9(2)7-4-5-10(3,6-7)8(9)11/h7H,4-6H2,1-3H3/t7-,10+/m0/s1
- Substance type: Organic
- Physical state: Liquid
Constituent 1
Test animals
- Species:
- other: Human
- Strain:
- other: Not applicable
- Details on test animals or test system and environmental conditions:
- No data
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Vehicle:
- other: Petrolatum
- Controls:
- not specified
- Amount / concentration applied:
- 4%
- Duration of treatment / exposure:
- 48 hours
- Observation period:
- 48 hours
- Number of animals:
- No Data Available
- Details on study design:
- No Data Available
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 48 h
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No known signs of skin irritation were observed.
- Other effects:
- No data
Applicant's summary and conclusion
- Interpretation of results:
- other: Not irritating
- Conclusions:
- The test chemical was considered to be not irritating to the skin of human subjects.
- Executive summary:
Skin irritation study of the given test chemical was conducted on human subjects to determine the degree of skin irritancy. Each subject was treated with 4% of test chemical in petrolatum dermally for 48 hours under a closed path patch. Since no known signs of irritation were observed, the chemical was considered to be not irritating to the skin of human subjects.
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