Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
26.02.2018 to 12.03.2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Version / remarks:
1995
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient - Shake Flask Method)
Version / remarks:
2008
GLP compliance:
yes (incl. QA statement)
Remarks:
consilab, Gesellschaft für Anlagensicherheit mbH, Industriepark Höchst, G830/G840, 65926 Frankfurt am Main (Germany)
Type of method:
flask method
Partition coefficient type:
octanol-water

Test material

Constituent 1
Reference substance name:
L-Threonine, N-coco acyl derivs., monosodium salts
Cas Number:
90583-79-2
Molecular formula:
n/a
IUPAC Name:
L-Threonine, N-coco acyl derivs., monosodium salts
Test material form:
solid
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Ajinomoto Co., Inc., 15-1, Kyobashi 1-chome, Chuo-ku, Tokyo 104-8315, Japan, Batch No.: 160329
- Expiration date of the lot/batch: 2019-03-29
- Purity test date: 2016-06-09

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: stored at ambient temperature

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficient
Key result
Type:
log Pow
Partition coefficient:
-2.6
Temp.:
20 °C
Remarks on result:
other: pH value not specified

Applicant's summary and conclusion

Conclusions:
The log Pow of the test item was determined to be -2.6 at 20°C.
Executive summary:

The n-octanol/water partition coefficient log Pow was investigated in a study conducted according to OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method; 1995) and EU Method A.8 (Partition Coefficient - Shake Flask Method; 2008). Based on the results of preliminary tests, the log Pow was determined via the solubilities of the test item in the pure solvents using HPLC/UV/VIS as analytical method. The log Pow of the test item was determined to be -2.6 at 20°C.

Categories Display