Registration Dossier
Registration Dossier
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EC number: 947-167-4 | CAS number: -
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
The registered substance is not acutely toxic via the oral route and investigation of an analogue substance via the dermal route gave the same conclusion (LD50 > 2000 mg/kg). Oral administration of an analogue test item to rats by gavage, at dose levels of 30, 100, 250 and 1000 mg/kg bw/day, was well tolerated in two subacute studies (28-day repeated dose oral toxicity and 28-day repeated dose oral toxicity study with reproductive/developmental toxicity screening) with the NOAEL reported as 1000 mg/kg bw/day in both cases.Moreover, no evidence of skin irritation/corrosion, serious eye damage/irritation or skin sensitisation was found during performance of appropriate studies.In the absence of systemic or local effects by the oral or dermal route a DNEL could not be derived.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
The registered substance is not acutely toxic via the oral route and investigation of an analogue substance via the dermal route gave the same conclusion (LD50 > 2000 mg/kg). Oral administration of an analogue test item to rats by gavage, at dose levels of 30, 100, 250 and 1000 mg/kg bw/day, was well tolerated in two subacute studies (28-day repeated dose oral toxicity and 28-day repeated dose oral toxicity study with reproductive/developmental toxicity screening) with the NOAEL reported as 1000 mg/kg bw/day in both cases. Moreover, no evidence of skin irritation/corrosion, serious eye damage/irritation or skin sensitisation was found during performance of appropriate studies. In the absence of systemic or local effects by the oral or dermal route a DNEL could not be derived.
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