Metam-sodium

Bioaccumulation: aquatic / sediment

Link to relevant study record(s)

Reference

Endpoint:

bioaccumulation in aquatic species, other

Remarks:

aquatic organisms

Type of information:

calculation (if not (Q)SAR)

Adequacy of study:

weight of evidence

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

secondary literature

Justification for type of information:

Data is from INERIS authoritative database

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

Determination of environmental bioconcentration factor of the test substance Metam-sodium.

GLP compliance:

not specified

Specific details on test material used for the study:

- Name of test material (IUPAC name): Metam-sodium
- Common name: Sodium methyldithiocarbamate
- Molecular formula: C2H5NNaS2
- Molecular weight: 129.1826 g/mol
- Smiles notation: C(=S)(NC)[S-].[Na+]
- InChl: 1S/C2H5NS2.Na/c1-3-2(4)5;/h1H3,(H2,3,4,5);/q;+1/p-1
- Substance type: Organic
- Physical state: Solid

Radiolabelling:

not specified

Vehicle:

not specified

Test organisms (species):

other: aquatic organisms

Route of exposure:

aqueous

Test type:

not specified

Water / sediment media type:

natural water: freshwater

Reference substance (positive control):

not specified

Type:

BCF

Value:

3.162 L/kg

Basis:

whole body w.w.

Remarks on result:

other: Other details not known

Validity criteria fulfilled:

not specified

Conclusions:

The estimated BCF (bioaccumulation factor) of test chemical Metam-sodium was determined to be 3.162 L/Kg.

Executive summary:

The bioaccumulation study in aquatic organisms was conducted for estimating the BCF (bioaccumulation factor) value of test chemical Metam-sodium (CAS no. 137-42-8). The estimated BCF (bioaccumulation factor) value of Metam-sodium was determined to be 3.162 L/Kg, which does not exceed the bioconcentration threshold of 2000, indicating that the chemical Metam-sodium is considered to be non-accumulative in aquatic organisms.

Description of key information

The bioaccumulation study in aquatic organisms was conducted for estimating the BCF (bioaccumulation factor) value of test chemical Metam-sodium (CAS no. 137-42-8)

(INERIS database, 2009). The estimated BCF (bioaccumulation factor) value of Metam-sodium was determined to be 3.162 L/Kg, which does not exceed the bioconcentration threshold of 2000, indicating that the chemical Metam-sodium is considered to be non-accumulative in aquatic organisms.

Key value for chemical safety assessment

BCF (aquatic species):

3.162 L/kg ww

Additional information

Experimental study and various predicted data for the target compound Metam-sodium (CAS No. 137-42-8) and supporting weight of evidence study for its structurally and functionally similar read across substance were reviewed for the bioaccumulation end point which are summarized as below:

 

In an experimental study from authoritative database (INERIS database, 2009), bioaccumulation study in aquatic organisms was conducted for estimating the BCF (bioaccumulation factor) value of test chemical Metam-sodium (CAS no. 137-42-8). The estimated BCF (bioaccumulation factor) value of Metam-sodium was determined to be 3.162 L/Kg.

 

Another bioaccumulation study in aquatic organisms was conducted for estimating the BCF (bioaccumulation factor) value of test chemical Metam-sodium (CAS no. 137-42-8) (Pesticide Properties Database, 2017). The estimated BCF (bioaccumulation factor) value of Metam-sodium was evaluated to be 0.03 L/Kg.

 

From CompTox Chemistry Dashboard using OPERA (OPEn (quantitative) structure-activity Relationship Application)  V1.02 model in which calculation based on PaDEL descriptors (calculate molecular descriptors and fingerprints of chemical), the bioaccumulation i.e BCF for test substance Metam-sodium was estimated to be 6.5 dimensionless . The predicted BCF result based on the 5 OECD principles.

 

In a supporting weight of evidence study from authoritative database (HSDB and PubChem, 2017) for the read across chemical 1,2-Ethanediylbiscarbamodithioic acid disodium salt (CAS no. 142-59-6),the bioaccumulation study in fish was conducted for estimating the BCF (bioaccumulation factor) value of read across chemical 1,2-Ethanediylbiscarbamodithioic acid disodium salt (CAS no. 142-59-6). The bioaccumulation factor (BCF) value was calculated using a log Kow of -4.24 and a regression-derived equation. The estimated BCF (bioaccumulation factor) value of 1,2 -Ethanediylbiscarbamodithioic acid disodium salt was determined to be 3 dimensionless.

 

On the basis of above results for target chemical Metam-sodium (from authoritative database INERIS Pesticide Properties databaseand CompTox Chemistry Dashboard,2017) and for its read across substance (from authoritative database HSDB and PubChem), it can be concluded that the BCF value of test substanceMetam-sodiumranges from 0.03 – 6.5 which does not exceed the bioconcentration threshold of 2000, indicating that the chemicalMetam-sodiumis not expected to bioaccumulate in the food chain.