Registration Dossier
Registration Dossier
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EC number: 947-279-3 | CAS number: -
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- January 2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- rel-(3R,3aS,7S,8aS)-3,6,8,8-tetramethyl-2,3,4,7,8,8a-hexahydro-1H-3a,7-methanoazulene
- Cas Number:
- 22567-43-7
- Molecular formula:
- C15H24
- IUPAC Name:
- rel-(3R,3aS,7S,8aS)-3,6,8,8-tetramethyl-2,3,4,7,8,8a-hexahydro-1H-3a,7-methanoazulene
- Reference substance name:
- rel-(3R,3aR,7R,8aS)-3,8,8-trimethyl-6-methyleneoctahydro-1H-3a,7-methanoazulene
- Cas Number:
- 1404220-60-5
- Molecular formula:
- C15H24
- IUPAC Name:
- rel-(3R,3aR,7R,8aS)-3,8,8-trimethyl-6-methyleneoctahydro-1H-3a,7-methanoazulene
- Reference substance name:
- rel-(3R,3aS,7S,8aS)-3,8,8-trimethyl-6-methyleneoctahydro-1H-3a,7-methanoazulene
- Cas Number:
- 65450-98-8
- Molecular formula:
- C15H24
- IUPAC Name:
- rel-(3R,3aS,7S,8aS)-3,8,8-trimethyl-6-methyleneoctahydro-1H-3a,7-methanoazulene
- Reference substance name:
- rel-(1R,9S,E)-4,11,11-trimethyl-8-methylenebicyclo[7.2.0]undec-4-ene
- Cas Number:
- 17627-40-6
- Molecular formula:
- C15H24
- IUPAC Name:
- rel-(1R,9S,E)-4,11,11-trimethyl-8-methylenebicyclo[7.2.0]undec-4-ene
- Reference substance name:
- rel-(1aR,4aR,8aR)-2,4a,8,8-tetramethyl-1,1a,4,4a,5,6,7,8-octahydrocyclopropa[d]naphthalene
- Cas Number:
- 32435-95-3
- Molecular formula:
- C15H24
- IUPAC Name:
- rel-(1aR,4aR,8aR)-2,4a,8,8-tetramethyl-1,1a,4,4a,5,6,7,8-octahydrocyclopropa[d]naphthalene
- Reference substance name:
- 1,8-dimethyl-4-(propan-2-ylidene)spiro[4.5]dec-7-ene
- Molecular formula:
- C15H24
- IUPAC Name:
- 1,8-dimethyl-4-(propan-2-ylidene)spiro[4.5]dec-7-ene
- Reference substance name:
- 1-methyl-4-(1,2,2-trimethylcyclopentyl)benzene
- Cas Number:
- 51773-81-0
- Molecular formula:
- C15H22
- IUPAC Name:
- 1-methyl-4-(1,2,2-trimethylcyclopentyl)benzene
- Test material form:
- liquid
- Details on test material:
- UVCB
Constituent 1
Constituent 2
Constituent 3
Constituent 4
Constituent 5
Constituent 6
Constituent 7
- Specific details on test material used for the study:
- Batch 9000343808
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- 0.5 ml
- Duration of treatment / exposure:
- 4 hrs
- Observation period:
- 1, 24, 48 and 72 hours and 7, 14 days after application.
- Number of animals:
- 3 (one male and two females)
- Details on study design:
- The primary irritation score was calculated to reflect and classify the irritant potential of the test article.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: Primary Irritation Score
- Score:
- 3.44
- Max. score:
- 8
- Reversibility:
- fully reversible within: 14d
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- positive indication of irritation
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Executive summary:
Application of Cedrene Washed to healthy intact rabbit skin resulted in a primary irritation score of 3.44.
Therefore Cedrene Washed is considered to be "Irritating" to rabbit skin.
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