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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1973
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: OSHA Toxicity Screening Test. Limited documentation of the study.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1973
Report Date:
1973

Materials and methods

Test guideline
Guideline:
other: OSHA Toxicity Screening Test
GLP compliance:
no
Test type:
other: single dose
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rabbit
Strain:
New Zealand White

Administration / exposure

Doses:
Dosage: 3000 mg/kg
No. of animals per sex per dose:
6

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
> 3 000 mg/kg bw
Based on:
test mat.
Mortality:
In the observation period of 14 days, 2 of 6 experimental animals died.
Clinical signs:
As signs of intoxiciation, only hypoactivity was reported.

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Conclusions:
In an acute dermal toxicity study on Isodecyl methacrylate with Albino Rabbits, an LD50 > 3000 mg/kg was observed.
Executive summary:

In an OSHA toxicity screening test in Albino rabbits on acute dermal toxicity with Isodecyl methacrylate, the test substance was administered undiluted with a dosage of 3000 mg/kg. b.w.

As sign of intoxication, hypoactivity is reported.

The determined LD50 was > 3000 mg/kg.

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