Registration Dossier
Registration Dossier
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EC number: 616-105-5 | CAS number: 74504-65-7
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics, other
- Type of information:
- other: weight of evidence assessment based on hydrolysis products and structural analogues
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other:
- Justification for type of information:
- No data is available for polyglycerol-2-caprate. The toxicokinetics of this substance is therefore assessed in a weight of evidence analysis based on existing data on similar compounds.
Data source
Materials and methods
Test material
- Reference substance name:
- Decanoic acid, 3-(2,3.dihydroxypropoxy)-2-hydroxypropyl ester
- EC Number:
- 605-046-0
- Cas Number:
- 156153-06-9
- Molecular formula:
- C16H32O6
- IUPAC Name:
- Decanoic acid, 3-(2,3.dihydroxypropoxy)-2-hydroxypropyl ester
Constituent 1
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Polyglycerol-2-caprate is hydrolysed in the stomach and in the intestine and is readily absorbed.
- Details on distribution in tissues:
- The majority of polyglycerol-2-caprate is distributed to the liver where it is further utilized.
- Details on excretion:
- Polyglycerol-2-caprate is excreted in the urine and feces, however, a large proportion is utilized and excreted as CO2
Metabolite characterisation studies
- Details on metabolites:
- The major hydrolysis products are glycerol and decanoic acid
Applicant's summary and conclusion
- Conclusions:
- Polyglycerol-2-caprate is hydrolysed and absorbed efficiently in the stomach and in the intestines and metabolised primarily in the liver.
- Executive summary:
No data exist on the toxicokinetics ofpolyglycerol-2-caprate, however, several data exist on the toxicokinetics of the polyglyceryls and the hydrolysis product decanoic acid. Documentation that polyglycerol fatty acid esters are hydrolysed and absorbed efficiently in the stomach and in the intestines exists and data show that fatty acids are readily absorbed and metabolised in the liver.
Asthe main constituent of polyglycerol-2-caprate is diglycerol and decanoic acid, the toxixcokinetics can be expected to be similar to what is described above.
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