Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 229-066-0
CAS number: 6408-72-6
Several valid acute oral toxicity studies according or similar to OECD
guideline 401 are available. The LD50 value in all studies was greater
than 5000 mg/kg bw (discriminating dose).
In a valid acute inhalation study according to OECD guideline 436 a LC50
greater than 5.04 mg/l (discriminating dose) was determined.
No study for acute dermal toxicity is available: According to Commission
Regulation (EU) 2016/863 of May 2016 acute toxicity testing by the
dermal route (Annex VII, point 8.5.3., column 2) ‘does not need to be
conducted if the substance does not meet the criteria for classification
as acute toxicity or STOT SE by the oral route and no systemic effects
have been observed in in vivo studies with dermal exposure’. The
registered substance conforms with the requirements given above.
Therefore, it can be concluded for acute dermal toxicity that the
available information is conclusive for non-classification.
A single dose of 5000 mg/kg bw of the test substance was applied to 5
male and 5 female Wistar rats per gavage. The animals were inspected
several times on the day of administration, and twice daily during the
following 14-day observation period. The dose of 5000 mg/kg body weight
was tolerated without adverse effects by all male and female animals.
No adverse gross pathological findings were observed. The LD50 is
greater than 5000 mg/kg bw (discriminating dose).
According to the acute oral toxicity studies the LD50 is greater than
5000 mg/kg bw (discriminating dose) and the acute inhalation LC50 value
is greater 5.04 mg/L (discriminating dose).
According to CLP classification criteria (Regulation (EC) No 1272/2008)
a classification is therefore not justified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again