Tagetes minuta, ext.

Boiling point

Link to relevant study record(s)

Reference

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

10 May 2017 - 13 July 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

The study was conducted according to an internationally recognised method. Test substance is adequately characterised. Therefore full validation applies.

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to other study

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling Point)

Version / remarks:

1995

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Version / remarks:

2008

Deviations:

no

Principles of method if other than guideline:

Not applicable

GLP compliance:

yes (incl. QA statement)

Remarks:

Inspected on 13 and 14 October 2014/ signed on 8 April 2015

Type of method:

method according to Siwoloboff

Key result

Boiling pt.:

201.9 °C

Atm. press.:

1 atm

Decomposition:

no

Pre-test following Siwoloboff:

Since 111 °C came every now and then bubbles. Boiling chain was observed at 194 °C. The gas burner was turned down at 202.5 °C and the boiling chain broke at 189 °C.

After cooling down no signs of decomposition were observed.

Security pre-test for DSC:

The black-brown test item came out from the crucible at the perforated hole after reaching a temperature of 420°C. The weight was recorded with 45.69 mg. After further heating to 600°C and cooling down outside test item was gone, the lid of crucible was bloated. The weight was recorded with 45.56 mg.

DSC results:

After first and second determination, no event was found. The crucible was visually unchanged. As no evaluable event was detected the sponsor was consulted. The determination of boiling point following Siwoloboff method was performed.

Results for Siwoloboff method:

The result was calculated as mean of the two values of the duplicate determination:

	Boiling point	Pressure in Pa	Corrected Boling point
First determination	201.6 °C (474.8 K)	100420 Pa	201.95 °C (475.10 K)
Second determination	201.4 °C (474.6 K)	100394 Pa	201.76 °C (474.91 K)
Mean			201.9 °C (475.0 K)

Conclusions:

Two determinations of boiling point were performed via DSC (differential scanning calorimetry) but no evaluable event was detected.
Therefore the boiling point of test item was determined following Siwoloboff method with:
 201.9 ± 0.1 °C (475.0 ± 0.1 K)
This value is the mean of two independent determinations.
Correction to standard pressure by Sidney-Young was made.

Executive summary:

The study was performed in order to determine the boiling point of test item according to OECD 103, resp EU A.2 guideline, using the DSC method or Siwoloboff method.

Two determinations of boiling point were performed via DSC (differential scanning calorimetry) but no evaluable event was detected.

Therefore the boiling point of test item was determined following Siwoloboff method with: 201.9 ± 0.1 °C (475.0 ± 0.1 K).

Description of key information

The boiling point of test item was determined following Siwoloboff method with: 201.9 ± 0.1 °C (475.0 ± 0.1 K)

Key value for chemical safety assessment

Boiling point at 101 325 Pa:

201.9 °C

Additional information

A fully reliable experimental study, conducted according to OECD 103/EU A2 guideline is available. It is considered as a key study, and the result is retained as key data.