Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 219-135-3 | CAS number: 2370-63-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1993-07-08 to 1993-07-22
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- adopted 24th February 1987
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 2-ethoxyethyl methacrylate
- EC Number:
- 219-135-3
- EC Name:
- 2-ethoxyethyl methacrylate
- Cas Number:
- 2370-63-0
- Molecular formula:
- C8H14O3
- IUPAC Name:
- 2-ethoxyethyl 2-methylprop-2-enoate
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): 2-ethoxyethyl methacrylate, MAEE
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Sprague-Dawley ICO: OFA-SD
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: app. 6 weeks
- Weight at study initiation: 189 ± 2 g (males), 158 ± 8 g (females)
- Fasting period before study: app. 18 h before and 4 h after dosing
- Housing: in groups of 5 by sex during treatment, polycarbonate cages covered with a stainless steel lid
- Diet (e.g. ad libitum): pelleted diet, ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22±3
- Humidity (%): 50±20
- Air changes (per hr): app. 13
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: bodyweights were recorded on days 1 (=day of treatment), 5, 8, 15; clinical signs: several times following application; at least once daily thereafter
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- act. ingr.
- Remarks on result:
- other: mortality: 0/10
- Mortality:
- No deaths occurred during the observation period.
- Clinical signs:
- No clinical signs were observed during the study period.
- Body weight:
- The body weight gain of the animals had slowed down slightly between days 1 and 5. Thereafter, between days 5 and 8, an increase of the body weight gain was noted. During the second week of the observation period, the body weight gain of the animals was normal.
- Gross pathology:
- Macroscopic examination of the main organs of the animals sacrificed at the end of the study revealed no apparent abnormalities.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The oral LD50 for ETMA in rats is > 2000 mg/kg bw.
- Executive summary:
In an acute oral toxicity study according to OECD guideline 401, adopted 24 February 1987, groups of fasted app. 6 week old Sprague-Dawley ICO: OFA-SD rats (5/sex) were given a single oral dose of ETMA (99.94% a.i.) by gavage at a dose level of 2000 mg/kg bw and observed for 14 days.
No deaths occurred during the observation period.
No clinical signs were observed during the study period.
The body weight gain of the animals had slowed down slightly between days 1 and 5. Thereafter, between days 5 and 8, an increase of the body weight gain was noted. During the second week of the observation period, the body weight gain of the animals was normal.
Macroscopic examination of the main organs of the animals sacrificed at the end of the study revealed no apparent abnormalities.
Oral LD50 (rat, male/female) > 2000 mg/kg bw
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
