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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation: in vivo (LLNA)
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2016
Report date:
2016

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method B.42 (Skin Sensitisation: Local Lymph Node Assay)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of study:
mouse local lymph node assay (LLNA)

Test material

Constituent 1
Chemical structure
Reference substance name:
(7-Methoxy-3,4-dihydronaphthalen-1-yl)acetonitrile
EC Number:
617-813-7
Cas Number:
861960-34-1
Molecular formula:
C13H13NO
IUPAC Name:
(7-Methoxy-3,4-dihydronaphthalen-1-yl)acetonitrile

In vivo test system

Study design: in vivo (LLNA)

Vehicle:
acetone/olive oil (4:1 v/v)

Results and discussion

In vivo (LLNA)

Resultsopen allclose all
Key result
Parameter:
other: Individual clinical observations and mortality data
Value:
ca. 0
Key result
Parameter:
other: Body change
Value:
>= -0.3 - <= 0.8
Key result
Parameter:
SI
Value:
ca. 1.35
Test group / Remarks:
10% V/V
Key result
Parameter:
SI
Value:
ca. 1.68
Test group / Remarks:
25% V/V
Key result
Parameter:
SI
Value:
ca. 1.16
Test group / Remarks:
50% V/V

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The test item was considered to be non-sensitizer to the skin.