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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2001
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2001
Report date:
2001

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
BONIFACE M. et B., CAZIN J.C et LUYCKX J. Calcul, sur ordinateur, de la dose efficace par la méthode des probits : Application au calcul d’une dose létale 50. Bull Soc. Pharm. Lille, 1972, 4, 187-185

CAZIN J.L. Exemples d’utilisation de micro-ordinateurs en génie biologique et médical (Apple II et III) Diplôme d’Etudes Approfondies de Génie Biologique et Médical. 1983, Faculté de Pharmacie de Lille.

BLISS C.I. The determination of the dosage-mortalité curve from small numbers. Quart J. Pharm., 1938, 11, 1926.
GLP compliance:
not specified
Test type:
fixed dose procedure
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
(7-Methoxy-3,4-dihydronaphthalen-1-yl)acetonitrile
EC Number:
617-813-7
Cas Number:
861960-34-1
Molecular formula:
C13H13NO
IUPAC Name:
(7-Methoxy-3,4-dihydronaphthalen-1-yl)acetonitrile

Test animals

Species:
rat
Strain:
Wistar
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: gommi arabicum
Doses:
5%

Results and discussion

Effect levels
Key result
Sex:
male
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat. (dissolved fraction)

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
Under the experimental conditions, the oral LD50 of the test item Hydrocyan is higher than 5000 mg/kg in rats