Registration Dossier
Registration Dossier
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EC number: 938-398-1 | CAS number: -
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The 48-hour EC50 of the substance was determined to be >138.68 mg/L (based on arithmetric mean measured concentrations).
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 138.68 mg/L
Additional information
In a 48-hour acute toxicity study (BASF SE 2018), neonate Daphnia magna were exposed to the test substance at nominal concentrations of 0 (control), 15.6, 31.5, 62.5, 125 and 250 mg/L, corresponding to 0, 3.60, 14.09, 31.33, 63.2 and 138.68 mg/L man measured concentrations under static conditions in accordance with OECD Guideline 202, EU Method C.2 and GLP principles. The test substance was stable in solution under test conditions and mean measured concentrations are an accurate representation of exposure levels maintained throughout the test period. In addition, a negative control (containing only M4 Medium, without the test item) and a positive control with the reference substance sodium chloride was performed. The water pH, temperature and dissolved oxygen were within acceptable guideline specifications. Immobilization (mortality) and sublethal effects were observed daily. In result, the 48-hour EC50 value for the test item was determined to be 250 mg/L nominal and 138.68 mg/L based on mean measured concentration in test media. The 48-h EC50 of the reference substance was determined to be 4.18 g/L. This result is within the range of 3.88 - 7.22 g/L and indicates that the culture of Daphnia magna used in this study is responding normally to toxic stress. All validity criteria of the guidelines were fulfilled.
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