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EC number: 288-538-4 | CAS number: 85750-13-6
Endpoint summary
Administrative data
Description of key information
Stability:
Hydrolysis:
Acoording to annex VIII column 2 the study does not need to be conducted because the substance 4-[(2-chloro-4-nitrophenyl)diazenyl]-N-ethyl-N-[2-[1-(2-methylpropoxy)ethoxy]ethyl]aniline is highly insoluble in water.
Biodegradation:
Biodegradation in water:
Estimation Programs Interface Suite (EPI suite, 2018) was run to predict the biodegradation potential of the test compound 4-[(2-chloro-4-nitrophenyl)diazenyl]-N-ethyl-N-[2-[1-(2-methylpropoxy)ethoxy]ethyl]aniline(CAS no. 85750 -13 -6) in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical 4-[(2-chloro-4-nitrophenyl)diazenyl]-N-ethyl-N-[2-[1-(2-methylpropoxy)ethoxy]ethyl]aniline is expected to be not readily biodegradable.
Transport and distribution:
Adsorption/desorption:
The Soil Adsorption Coefficient i.e. Koc value of test chemical 4-[(2-chloro-4-nitrophenyl)diazenyl]-N-ethyl-N-[2-[1-(2-methylpropoxy)ethoxy]ethyl]aniline (CAS No. 85750-13-6) was estimated using EPI suite KOCWIN Program (v2.00) as 30500 L/kg (log Koc= 4.484) by means of MCI method at 25 deg. C. This log Koc value indicates that test chemical 4-[(2-chloro-4-nitrophenyl)diazenyl]-N-ethyl-N-[2-[1-(2-methylpropoxy)ethoxy]ethyl]aniline has very strong sorption to soil and therefore test chemical has negligible migration potential to ground water.
Additional information
Stability:
Hydrolysis:
Acoording to annex VIII column 2 the study does not need to be conducted because the substance 4-[(2-chloro-4-nitrophenyl)diazenyl]-N-ethyl-N-[2-[1-(2-methylpropoxy)ethoxy]ethyl]aniline is highly insoluble in water.
Biodegradation:
Biodegradation in water:
Predicted data study for target chemical 4-[(2-chloro-4-nitrophenyl)diazenyl]-N-ethyl-N-[2-[1-(2-methylpropoxy)ethoxy]ethyl]aniline(CAS no. 85750 -13 -6) and supporting weight of evidence study for its read across chemical have been reviewed for biodegradation endpoint.
In a predicted data study Estimation Programs Interface Suite (EPI suite, 2018) was run to predict the biodegradation potential of the test compound 4-[(2-chloro-4-nitrophenyl)diazenyl]-N-ethyl-N-[2-[1-(2-methylpropoxy)ethoxy]ethyl]aniline(CAS no. 85750 -13 -6) in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical 4-[(2-chloro-4-nitrophenyl)diazenyl]-N-ethyl-N-[2-[1-(2-methylpropoxy)ethoxy]ethyl]aniline is expected to be not readily biodegradable.
Next study was reviewed from authoritative database in this study the Biodegradation experiment was carried out of test chemical by taking activated sludge as inoculums at 100 mg/L concentration for 28 days. Biodegradation was analyzed by using two parameters that are BOD and UV vis .The initial concentration of test chemical was 30 mg/L. After 4 weeks of incubation percent biodegradation of test chemical was observed 0.0 % by BOD parameter 4.0 % by UV vis parameter in 28 days. Therefore it is concluded that test chemical not readily biodegradable.
Another study was also experimental reviewed from authoritative database in this study the Biodegradation experiment was conducted for 28 days for evaluating the percentage biodegradability of test chemical. Concentration of inoculum i.e, sludge u1 -(4 -Methyl-2 -nitrophenylazo)-2 -naphthosed was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of test substance was determined to be 0 and 1% by BOD and HPLC parameter in 28 days. Thus, based on percentage degradation value is considered to be not readily biodegradable in nature.
On the basis of results of all the studies mentioned above it can be concluded that test chemical 4-[(2-chloro-4-nitrophenyl)diazenyl]-N-ethyl-N-[2-[1-(2-methylpropoxy)ethoxy]ethyl]aniline (CAS no. 85750 -13 -6) is expected to be not biodegradable.
Transport and distribution:
Adsorption/desorption:
Various predicted data studies for target chemical and experimental studies for its structurally similar read across chemical have been reviewed for adsorption endpoint and their results are summarized below.
In first predicted data study the Soil Adsorption Coefficient i.e. Koc value of test chemical 4-[(2-chloro-4-nitrophenyl)diazenyl]-N-ethyl-N-[2-[1-(2-methylpropoxy)ethoxy]ethyl]aniline (CAS No. 85750-13-6) was estimated using EPI suite KOCWIN Program (v2.00) as 30500 L/kg (log Koc= 4.484) by means of MCI method at 25 deg. C.
In another study the Soil Adsorption Coefficient i.e Koc value of test substance 4-[(2-chloro-4-nitrophenyl)diazenyl]-N-ethyl-N-[2-[1-(2-methylpropoxy)ethoxy]ethyl]aniline (CAS no.85750 -13 -6) was estimated using Adsorption Coefficient module (v12.1.0.50374) program of Advanced Chemistry Development/I-lab predictive module as Koc 349102 dimensionless (log Koc= 5.5429) at pH 7.
Next predicted data study was done by using Sci Finder database the soil adsorption co-efficient i.e., Koc value of test chemical 4-[(2-chloro-4-nitrophenyl)diazenyl]-N-ethyl-N-[2-[1-(2-methylpropoxy)ethoxy]ethyl]aniline was estimated to be 322000 dimensionless (log Koc = 5.5078) at pH range 6-10 at temperature 25 deg.c.
Another predicted data study was done by using Chemspider-ACD/Phy chem suite the soil adsorption co-efficient i.e., Koc value of test substance 4-[(2-chloro-4-nitrophenyl)diazenyl]-N-ethyl-N-[2-[1-(2-methylpropoxy)ethoxy]ethyl]aniline (CAS no. 85750 -13 -6) was estimated to be 78069.40 dimensionless (log Koc= 4.8924) at pH 5.5 and 78153.20 dimensionless (Log Koc= 4.8929) at pH 7.4 and temperature 25 deg.C
Next study was experimental study reviewed from authoritative database (HSDB) in this study the Adsorption study was conducted for estimating the adsorption coefficient (Koc) value of test chemical. The adsorption coefficient (Koc) value was calculated using a structure estimation method based on molecular connectivity indices. The adsorption coefficient (Koc) value of test substance was estimated to be 230000 (Log Koc = 5.361).
Last study was also experimental study done from authoritative database (HSDB) in this study Adsorption study was conducted for estimating the adsorption coefficient (Koc) value of test chemical . The adsorption coefficient (Koc) value was calculated using a structure estimation method based on molecular connectivity indices. The adsorption coefficient (Koc) value of test substance was estimated to be 130000 (Log Koc = 5.113).
By considering results of all the studies mentioned above it can be concluded that log Koc value of test chemical is in range of 4.484 - 5.5429. This range log Koc value indicates that that the chemical 4-[(2-chloro-4-nitrophenyl)diazenyl]-N-ethyl-N-[2-[1-(2-methylpropoxy)ethoxy]ethyl]aniline has very strong sorption to soil and sediments and therefore test chemical has negligible migration potential to ground water.
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