Registration Dossier
Registration Dossier
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EC number: 268-048-7 | CAS number: 67990-27-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- data is from safety assessment reports
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Acute Oral toxicity test was carried out to study the effects of test chemical on rats.
- Author:
- Commission of the European Communities
- Year:
- 1 988
- Bibliographic source:
- Scientific Committee on Cosmetology (seventh series), European Communities
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Acute oral toxicity study of test chemical in rats
- GLP compliance:
- not specified
- Test type:
- other: No data available
- Limit test:
- yes
Test material
- Reference substance name:
- 1-(2-methyl-4-(2-methylphenylazo)phenylazo)-2-naphthol
- EC Number:
- 201-635-8
- EC Name:
- 1-(2-methyl-4-(2-methylphenylazo)phenylazo)-2-naphthol
- Cas Number:
- 85-83-6
- Molecular formula:
- C24H20N4O
- IUPAC Name:
- 1-(2-methyl-4-(2-methylphenylazo)phenylazo)-2-naphthol / 85-83-6 / 201-635-8
- Details on test material:
- - Name of test material:C.I. Solvent Red 24
- Molecular formula :C24H20N40
- Molecular weight :380.48 g/mole
- Smiles notation: c12c(\N=N\c3c(cc(\N=N\c4c(cccc4)C)cc3)C)c(ccc1cccc2)O
- InChl: 1S/C24H20N4O/c1-16-7-3-6-10-21(16)26-25-19-12-13-22(17(2)15-19)27-28-24-20-9-5-4-8-18(20)11-14-23(24)29/h3-15,29H,1-2H3/b26-25+,28-27+
- Substance type:Organic
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No data available
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality observed
- Mortality:
- No mortality was observed at dose 5000 mg/kg bw
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
- Conclusions:
- The LD50 value was considered to be > 5000 mg/kg bw,when rats were treated with test chemical orally.
- Executive summary:
In a acute oral toxicity study,rats were treated with test chemical in the concentration of 5000 mg/kg bw orally. No mortality observed in treated rats at 5000 mg/kg bw. Therefore,LD50 was considered to be > 5000 mg/kg bw,when rats were treated with test chemical orally.
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