Registration Dossier

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Short-term EC50 and NOEC values for Adenosine (CAS no.58-61-7) are available for two trophic levels of the aquatic freshwater compartment (aquatic invertebrates, algae) from GLP studies according to OECD 201 and 202.

Additional information

Algae:

The acute toxicity of Adenosine (CAS no. 58-61-7) to the green alga Desmodesmus subspicatus was determined in a 72 hour static test according to OECD guideline 201. The median effect concentrations (EC50) of Adenosine on the green alga Desmodesmus subspicatus was estimated to be >100 mg/l nominal concentration after 72 h of exposure. The NOEC values were determined to be 100 mg/l nominal concentration after 72 h of exposure. The results of the test can be considered reliable without restriction.

Daphnia:

The acute toxicity of Adenosine (CAS no. 58-61-7) to Daphnia magna was determined in a 48 hour semi-static test according to OECD guideline 202. The median effect concentrations (EC50) of Adenosine on Daphnia magna were estimated to be >120 mg/l nominal concentration after 24 and 48 h of exposure, respectively. The NOEC values were determined to be 120 mg/l nominal concentration after 24 and 48 h of exposure, respectively. The results of the test can be considered reliable without restriction.

 

Conclusion on classification

The environmental classification of Adenosine (CAS no. 58-61-7) is currently not harmonised according to the CLP Regulation (EC) 1272/2008. Based on available acute aquatic toxicity data, the lowest valid effect concentration for freshwater aquatic organisms is >100 mg/L (EC50 for algae). Based on the available acute data, the substance should not be classified for acute toxicity following Annex I, table 4.1.0a of the CLP regulation (there are no acute values <=1 mg/L).