Registration Dossier

Administrative data

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
12 October 2017 - 12 January 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
2006
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
Qualifier:
according to
Guideline:
EPA OPPTS 830.7950 (Vapor Pressure)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
effusion method: Knudsen cell

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
impurity
Test material form:
solid: particulate/powder
Details on test material:
Batch No.: 10004539
Storage at room temperature approx. 20°C

Results and discussion

Vapour pressureopen allclose all
Key result
Temp.:
20 °C
Vapour pressure:
< 0.009 Pa
Remarks on result:
other: estimated on the basis of the maximum measured vapour pressures
Key result
Temp.:
25 °C
Vapour pressure:
< 0.009 Pa
Remarks on result:
other: estimated on the basis of the maximum measured vapour pressures
Key result
Temp.:
50 °C
Vapour pressure:
< 0.009 Pa
Remarks on result:
other: estimated on the basis of the maximum measured vapour pressures

Any other information on results incl. tables

In three measurements, the vapour pressure was determined for 7 temperatures in the temperature range of 51 – 131 °C.

Due to the fact that the test item showed no proper linear correlation of the vapour pressure and the inverse temperature 1/T, the Antoine constants could not be evaluated in the measured temperature range. Therefore, the vapour pressure was estimated on the basis of the maximum measured vapour pressures for the temperatures 20, 25 and 50°C. The measured vapour pressure values together with the measured temperatures are listed in the table in the next section "overall remarks".

Applicant's summary and conclusion

Conclusions:
The test item Adenosine (CAS no. 58-61-7) showed no evaluable vapour pressure curve in the temperature range of 51 to 131 °C. Due to this result, the vapour pressures for the temperatures 20, 25 and 50 °C are estimated on the basis of the maximum measured vapour pressures, according to Regulation EC No. 440/2008 Method A.4. The vapour pressure of the test item was 0.0092 Pa at 20°C, 25°C and 50°C.
Executive summary:

The test item Adenosine (CAS no. 58-61-7) showed no evaluable vapour pressure curve in the temperature range of 51 to 131 °C. Due to this result, the vapour pressures for the temperatures 20, 25 and 50 °C are estimated on the basis of the maximum measured vapour pressures, according to Regulation EC No. 440/2008 Method A.4. The vapour pressure of the test item was 0.0092 Pa at 20°C, 25°C and 50°C.