Registration Dossier

Administrative data

Endpoint:
boiling point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
12 October 2017 - 12 January 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
EU Method A.2 (Boiling Temperature)
Deviations:
no
Qualifier:
according to
Guideline:
OECD Guideline 103 (Boiling Point)
Deviations:
no
Qualifier:
according to
Guideline:
EPA OPPTS 830.7220 (Boiling Point / Boiling Range)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
differential scanning calorimetry

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
impurity
Test material form:
solid: particulate/powder
Details on test material:
Batch No.: 10004539
Storage at room temperature approx. 20°C

Results and discussion

Boiling point
Key result
Atm. press.:
>= 1 014 - <= 1 016 hPa
Decomposition:
yes
Decomp. temp.:
ca. 250 °C
Remarks on result:
other: No boiling point up to its decomposition starting at a temperature of approx. 250 °C

Any other information on results incl. tables

In the temperature range of 230 – 250 °C, an endothermic effect was observed, which be assigned to the melting of the test item. The endothermic effect was directly followed by an exothermic effect in the temperature range of 250 – 300 °C, with an average decomposition energy of -220 J/g. No further thermal effects were observed up to the test end temperature of 500 °C.

Since no second endothermic effect could be observed up the decomposition of the test item starting at a temperature of approx. 250 °C it can be stated that the test item Adenosine (CAS no. 58-61-7) has no boiling point.

To verify the results of the DSC measurement, two additional measurements with the capillary method (Apparatus: Stuart Melting Point SMP30) were performed in the temperature range of 150 – 350 °C with a heating rate of 10 K/min. The test item changed its colour from white to black starting at a temperature of approx. 260 °C and expands throughout the capillary. Due to this result, the test item has no boiling point before its decomposition starting at a temperature of about 250 °C. 

The detailed results of the DSC-measurements are given in the table in the field 'Overall remarks'.

Applicant's summary and conclusion

Conclusions:
The test item Adenosine (CAS no. 58-61-7) has no boiling point up to its decomposition starting at a temperature of approx. 250 °C at atmospheric pressure (1014 – 1016 hPa) as determined by differential scanning calorimetry according to Regulation EC No. 440/2008 Method A.2. and OECD Test Guideline 103 (1995).
Executive summary:

The test item Adenosine (CAS no. 58-61-7) has no boiling point up to its decomposition starting at a temperature of approx. 250 °C at atmospheric pressure (1014 – 1016 hPa) as determined by differential scanning calorimetry according to Regulation EC No. 440/2008 Method A.2. and OECD Test Guideline 103 (1995).