Adenosine

Auto flammability

Administrative data

Endpoint:

relative self-ignition temperature (solids)

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

other:

Justification for type of information:

See further information in the cross-ref.

Cross-reference

Reason / purpose for cross-reference:

data waiving: supporting information

Reference

Endpoint:

self-heating substances / mixtures

Type of information:

experimental study

Adequacy of study:

key study

Study period:

17 - 19 October 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

other: UN Recommendations on the TRANSPORT OF DANGEROUS GOODS: Manual of Tests and Criteria

Version / remarks:

Rev. 6 (2015)

Deviations:

no

Qualifier:

according to guideline

Guideline:

other: VDI 2263 Sheet 1 Grewer Oven

Version / remarks:

1990

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Key result

Test procedure:

other: Grewer oven

Remarks:

pure test item

Result:

other: An endothermic process was detected starting at a temperature of approx. 220 °C, which can be assigned to the melting of the test item.

Remarks on result:

other: no self-heating observed at atmospheric pressure up to its melting temperature of approx. 220 °C.

Key result

Test procedure:

other: Grewer oven

Remarks:

test item in mixture with Kieselguhr

Max. temp. reached:

330

Result:

other: temperature increase was observed starting at 230°C

Key result

Test procedure:

other: Grewer oven

Remarks:

test item in mixture with Kieselguhr

Max. temp. reached:

600

Result:

other: temperature increase was observed starting at 350°C

In the investigation of self-ignition in the Grewer Oven for the pure test item an endothermic process was detected starting at a temperature of approx. 220 °C, which can be assigned to the melting of the test item. No further thermal processes could be observed up the maximum test temperature of approx. 420 °C. After the measurement a swollen black residue remained in the wire basket.

For the test item in mixture with Kieselguhr an endothermic process was detected starting at a temperature of approx. 220 °C, which can be assigned to the melting of the test item. The endothermic effect is directly followed by an exothermic process starting at a temperature of approx. 230 °C that led to a maximum temperature of approx. 330 °C (corresponding oven temperature 240 °C). A further exothermic effect was observed starting at a temperature of 350 °C, which led to a maximum temperature of approx. 600 °C (corresponding oven temperature 410 °C).

Interpretation of results:

not classified based on GHS criteria

Conclusions:

The pure test item Adenosine (CAS no. 58-61-7) indicated no self-heating at atmospheric pressure up to its melting temperature of approx. 220 °C.
On the basis to the results of the tests on the self-ignition in the Grewer Oven the test item is classified as follows:
UN Transport Regulation: The test item is not classified as self-heating substance in class 4, division 4.2 according to the UN Transport Regulation.
GHS / CLP Regulation EC 1272/2008 Annex 1: 2.11: The test item is not classified as self-heating substance according to GHS/CLP Regulation EC 1272/2008 Annex 1: 2.11, respectively.

Executive summary:

The pure test item Adenosine (CAS no. 58-61-7) indicated no self-heating at atmospheric pressure up to its melting temperature of approx. 220 °C.  

On the basis to the results of the tests on the self-ignition in the Grewer Oven the test item is classified as follows:  

UN Transport Regulation: The test item is not classified as self-heating substance in class 4, division 4.2 according to the UN Transport Regulation.

GHS / CLP Regulation EC 1272/2008 Annex 1: 2.11: The test item is not classified as self-heating substance according to GHS/CLP Regulation EC 1272/2008 Annex 1: 2.11, respectively.