Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 207-028-4 | CAS number: 423-55-2
Eye irritation
Administrative data
- Endpoint:
- eye irritation, other
- Remarks:
- in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 23 May 1990 - 26 May 1990
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: Internal, similar to OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1-bromoheptadecafluorooctane
- EC Number:
- 207-028-4
- EC Name:
- 1-bromoheptadecafluorooctane
- Cas Number:
- 423-55-2
- Molecular formula:
- C8BrF17
- IUPAC Name:
- 1-bromoheptadecafluorooctane
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Physical state/Appearance: Clear colourless liquidStorage condition of test material: Room temperature
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Age of animals at study initiation: AdultWeight at study initiation: 2.0 -3.5 kgAcclimation period: At least 7 days Environmental controls for the animal room was set to maintain a temperature of 70 deg F ±3 deg F, a relative humidity of 50% ±20%, and a 12-hour light/12-hour dark cycle.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: The other eye on the animal served as control
- Amount / concentration applied:
- 0.1 mL
- Observation period (in vivo):
- 72 hours
- Number of animals or in vitro replicates:
- 3 male and 3 female
- Details on study design:
- Each rabbit received 0.1 mL of the test material placed into the everted lower lid of one eye, with the contralateral eye serving as the untreated control. The upper and lower lids were gently held together for one second to prevent loss of material and then released. The eyes of the rabbits remained unflushed.The treated eyes were observed for ocular irritation at 1, 24, 48, and 72 hours after treatment. At the 72 -hour reading, sodium fluorescein was used to aid in revealing possible corneal injury. Irritation was graded and scored according to the Draize technique.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 1 h
- Score:
- 0
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 0
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 0
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 0
- Irritant / corrosive response data:
- No signs of eye irritation were noted in any of the animals. No pain response was elicited from any animal following instillation of the test material.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test material, Imagent GI (PFOB), produced no ocular irritation when instilled into the eyes of six albino rabbits.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
