Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Biodegradation in water: screening tests

Currently viewing:

Administrative data

biodegradation in water: ready biodegradability
Type of information:
Adequacy of study:
supporting study
Study period:
(January 2017)
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Data source

Materials and methods

Principles of method if other than guideline:
QSAR EPI Suite (v4.11) - Probability of Rapid Biodegradation (BIOWIN v4.10)
GLP compliance:

Results and discussion

Any other information on results incl. tables

The QSAR predictions using BIOWIN, part of the USEPA EPisuite software, is below.  It concludes that it is non-readily biodegradation based on all 7 tools.


Probability of Rapid Biodegradation (BIOWIN v4.10):

   Biowin1 (Linear Model)         :  -1.3441

   Biowin2 (Non-Linear Model)     :   0.0000

Expert Survey Biodegradation Results:

   Biowin3 (Ultimate Survey Model):   0.1277  (recalcitrant)

   Biowin4 (Primary Survey Model) :   1.8148  (months      )

MITI Biodegradation Probability:

   Biowin5 (MITI Linear Model)    :   0.0932

   Biowin6 (MITI Non-Linear Model):   0.0000

Anaerobic Biodegradation Probability:

   Biowin7 (Anaerobic Linear Model): -1.1444

Ready Biodegradability Prediction:   NO

Applicant's summary and conclusion

Interpretation of results:
not readily biodegradable
Based on its structural properties, the estimated probability of primary or ultimate degradation of PFOB during waste water treatment was low; PFOB is predicted to be recalcitrant. PFOB is not predicted to be readily biodegradable.