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Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1977
Report date:
1977

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Consumer Product Safety Commission of the USA in the Code of Federal Regulations, Title, 16, Section 1500.4 1.
Deviations:
yes
Remarks:
Due to the severity of the reactions three animals only were used.
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
2-Propanamine, compd. with boron trifluoride, reaction products with Bu glycidyl ether
EC Number:
270-846-5
EC Name:
2-Propanamine, compd. with boron trifluoride, reaction products with Bu glycidyl ether
Cas Number:
68478-97-7
Molecular formula:
C10H23BF3NO2
IUPAC Name:
2-propanamine, compd. with boron trifluoride, reaction products with butyl glycidyl
Test material form:
liquid: viscous

Test animals

Species:
rabbit
Strain:
not specified

Test system

Type of coverage:
occlusive
Preparation of test site:
clipped
Vehicle:
unchanged (no vehicle)
Controls:
no
Amount / concentration applied:
0.5 ml of pure material
Duration of treatment / exposure:
24 h exposure period
Observation period:
24 h and 72 h
Number of animals:
3
Details on study design:
Testing was performed according to the above reference and is briefly
summarized as follows :
3 rabbits were clipped free of hair. On one side of the animal was the skin abraded.
The sample (0.5 ml ) was then applied directly to the exposed skin and abraded skin of each animal and was covered with gauze squares which were securely taped and wrapped.
At the end of a 24-hour exposure period, the bandages were removed and the sample was washed from the skin.
Dermal reactions, erythema, edema, and necrosis were evaluated at 24 and 72 hours after exposure.

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
edema score
Basis:
animal #1
Time point:
72 h
Score:
2
Reversibility:
not specified
Remarks on result:
other: Abraded skin
Irritation parameter:
edema score
Basis:
animal #2
Time point:
72 h
Score:
2
Reversibility:
not specified
Remarks on result:
other: Abraded skin
Irritation parameter:
edema score
Basis:
animal #3
Time point:
72 h
Score:
3
Reversibility:
not specified
Remarks on result:
other: Abraded skin
Irritation parameter:
edema score
Basis:
animal #1
Time point:
24 h
Score:
3
Reversibility:
not specified
Remarks on result:
other: Abraded skin
Irritation parameter:
edema score
Basis:
animal #2
Time point:
24 h
Score:
3
Reversibility:
not specified
Remarks on result:
other: Abraded skin
Irritation parameter:
edema score
Basis:
animal #3
Time point:
24 h
Score:
3
Reversibility:
not specified
Remarks on result:
other: Abraded skin
Irritation parameter:
edema score
Basis:
animal #1
Time point:
72 h
Score:
2
Reversibility:
not specified
Remarks on result:
other: Clipped skin
Irritation parameter:
edema score
Basis:
animal #2
Time point:
72 h
Score:
2
Reversibility:
not specified
Remarks on result:
other: Clipped skin
Irritation parameter:
edema score
Basis:
animal #3
Time point:
72 h
Score:
1
Reversibility:
not specified
Remarks on result:
other: Clipped skin
Irritation parameter:
edema score
Basis:
animal #1
Time point:
24 h
Score:
3
Reversibility:
not specified
Remarks on result:
other: Clipped skin
Irritation parameter:
edema score
Basis:
animal #2
Time point:
24 h
Score:
3
Reversibility:
not specified
Remarks on result:
other: Clipped skin
Irritation parameter:
edema score
Basis:
animal #3
Time point:
24 h
Score:
3
Reversibility:
not specified
Remarks on result:
other: Clipped skin
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
72 h
Score:
4
Reversibility:
not specified
Remarks on result:
other: Abraded skin
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
72 h
Score:
4
Reversibility:
not specified
Remarks on result:
other: Abraded skin
Irritation parameter:
erythema score
Basis:
animal #3
Time point:
72 h
Score:
4
Reversibility:
not specified
Remarks on result:
other: Abraded skin
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
24 h
Score:
4
Reversibility:
not specified
Remarks on result:
other: Abraded skin
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
24 h
Score:
4
Reversibility:
not specified
Remarks on result:
other: Abraded skin
Irritation parameter:
erythema score
Basis:
animal #3
Time point:
24 h
Score:
4
Reversibility:
not specified
Remarks on result:
other: Abraded skin
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
72 h
Score:
4
Reversibility:
not specified
Remarks on result:
other: Clipped skin
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
72 h
Score:
4
Reversibility:
not specified
Remarks on result:
other: Clipped skin
Irritation parameter:
erythema score
Basis:
animal #3
Time point:
72 h
Score:
2
Reversibility:
not specified
Remarks on result:
other: Clipped skin
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
24 h
Score:
4
Reversibility:
not specified
Remarks on result:
other: Clipped skin
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
24 h
Score:
4
Reversibility:
not specified
Remarks on result:
other: Clipped skin
Irritation parameter:
erythema score
Basis:
animal #3
Time point:
24 h
Score:
3
Reversibility:
not specified
Remarks on result:
other: Clipped skin
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 24 h
Score:
3.7
Max. score:
4
Reversibility:
no data
Remarks on result:
other: Clipped skin
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 24 h
Score:
4
Max. score:
4
Reversibility:
no data
Remarks on result:
other: Abraded skin
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 72 h
Score:
3.3
Max. score:
4
Reversibility:
no data
Remarks on result:
other: Clipped skin
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 72 H
Score:
4
Max. score:
4
Reversibility:
no data
Remarks on result:
other: Abraded skin
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 24 h
Score:
3
Max. score:
4
Reversibility:
no data
Remarks on result:
other: Clipped skin
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 24 h
Score:
3
Max. score:
4
Reversibility:
no data
Remarks on result:
other: Abraded skin
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 72 h
Score:
1.7
Max. score:
4
Reversibility:
no data
Remarks on result:
other: Clipped skin
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 72 h
Score:
2.3
Max. score:
4
Reversibility:
no data
Remarks on result:
other: Abraded skin
Irritant / corrosive response data:
Severe "in deptht' skin damage with necrosis and small capillary hamorrhages was observed in all three animals at the 24 hours reading.
Similar reactions were seen at the 72 hours reading, although there was some reduction in the degree of oedema.

Applicant's summary and conclusion

Interpretation of results:
Category 1C (corrosive) based on GHS criteria
Conclusions:
Boron (2-propanamine) trifluoro-, rxn prod with butyl glycidyl ether was found to be corrosive in study using Consumer Product Safety Commission of the USA in the Code of Federal Regulations, Title, 16, Section 1500.4 1. test method with rabbits.
Executive summary:

Boron (2-propanamine) trifluoro-, rxn prod with butyl glycidyl etherwas tested for corrosivity using Consumer Product Safety Commission of the USA in the Code of Federal Regulations, Title, 16, Section 1500.4 1. test method with rabbits. Severe skin corrosion was observed in all three animals at the 24 hours reading. Similar reactions were seen at the 72 hours reading, although there was some reduction in the degree of oedema.