Methyl α-D-glucoside

Endpoint summary

Description of key information

- QSAR estimation of short-term toxicity to fish, 96h, descriptor: mortality: LC50 = 1.77E6 mg/L

- OECD guideline study (202), GLP, short-term toxicity to auqatic invertebrates (Daphnia magna), 48h, static condictions, freshwater, immobilisation: EC50 was not determineable, no toxic effects at concentrations up to limit concentration, (EC0) NOEC >100 mg/L

- OECD guideline study (201), GLP, toxicity to aquatic algae and cyanobacteria (Raphidocelis subcapitata), 72h, static conditions, freshwater, growth rate and yield,

EC50 was not determineable, no toxic effects at concentrations up to limit concentration, (EC0) NOEC > 125.3 mg/L

Additional information

For the assessment of the aquatic toxicity of alpha methyl glucoside short-term toxicity data with aquatic invertebrates and algae are available. Due to its readily biodegradability and the absence of toxic effects in these studies, testing of short-term toxicity to fish scientifically not justified. A detailed explanation is given below:

Toxicity to aquatic algae and cyanobacteria

There are adequate and reliable data regarding toxicity to aquatic algae and cyanobacteria available. In a study conducted according to OECD guideline 201 (adopted 28 July, 2011), GLP, green alga (Raphidocelis subcapitata) were exposed to geometric mean measured concentrations of 7.77, 14.0, 29.4, 55.1 and 125.3 mg/L for 72h under static condictions. No alterations in growth rate or yield or any adverse effect was observed, thus, the NOEC was considered to be > 125.3 mg/L. Moreover, due to the absence of any detectable effect the LOEC was also set to 125.3 mg/L.

Short-term toxicity to aquatic invertebrates

The 48h-acute toxicity of alpha methyl glucoside to Daphnia magna was studied under static condictions according to OECD guideline 202 (13 April, 2004), GLP. Daphnids were exposed to control and test chemical at nominal concentrations of 6.25, 12.5, 25.0, 50.0 and 100.0 mg a.s./L in purified drinking water for 48h. Mortality/immobilization was observed daily. The 48 -hour (EC0) NOEC was considered to be > 100 mg/L. Due to the absence of any other detectable effect the LOEC was also set to 100 mg/L.

Short-term toxicity to fish

No experimental data are available for the short-term toxicity to fish, therefore a QSAR prediction was performed using The Estimation Programs Interface (EPI) SuiteTM containing ECOSAR v1.11 (ECOlogical Structure Activity Relationship) Class Programm for Microsoft Windows; U.S. Environmental Protection Agency; Office of Chemical Safety and Pollution Prevention (Kelly Mayo-Bean, June 19, 2012). Since, the structural features as well as the molecular weight and the test substance logKow are within the recommended range for reliable results, the estimation is considered to be valid. The prediction revealed the following values for aquatic toxicity: short-term toxicity to fish, 96h-LC50 = 1.77E6 mg/L; short-term toxicity to aquatic invertebrates 48h-LC50 = 6.63E5 mg/L and toxicity to aquatic algae and cyanobacteria 96h-EC50 = 88454.055 mg/L. All estimated values are far above the limit concentration of 100 mg/L. Due to the nominal maximum concentration tested in both experimental studies (100 mg/L) the determined QSAR values are considered to be in agreement with the results of these studies.