Registration Dossier
Registration Dossier
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EC number: 201-851-2 | CAS number: 88-68-6
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP, non guideline study, available as unpublished report, limitations in design and/or reporting but otherwise adequate for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- According to BASF-internal standard. Two rabbits (1 male, 1 female) were dermally exposed to the test substance followed by a 8 day observation period. Test areas where the back and the ear of the rabbit.
- GLP compliance:
- no
Test material
- Reference substance name:
- Anthranilamide
- EC Number:
- 201-851-2
- EC Name:
- Anthranilamide
- Cas Number:
- 88-68-6
- Molecular formula:
- C7H8N2O
- IUPAC Name:
- 2-aminobenzamide
- Details on test material:
- Name of the test substance used in the study report: Anthranilsaeureamid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- - Weight of female animal: 2.93 kg
- Weight of male animal: 3.4 kg
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Amount / concentration applied:
- about 1 g of a 50 % aqueous preparation
- Duration of treatment / exposure:
- 1, 5, and 15 minutes and 20 hours
- Observation period:
- 8 days
- Number of animals:
- 2
- Details on study design:
- TEST SITE
- Area of exposure: The back of the animals
- Application area: 2.5 x 2.5 cm:
- Type of wrap if used: Cotton pad for the back of the animals
REMOVAL OF TEST SUBSTANCE
- Washing: Lutrol 50%
- Time after start of exposure: 20 hours
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: no effects were observed 8 days after 20 hours exposure
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: no effects were observed 8 days after 20 hours exposure
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: no effects were observed 8 days after 20 hours exposure
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: no effects were observed 8 days after 20 hours exposure
- Irritant / corrosive response data:
- Also no effects observed after 1, 5, and 15 minute and 20 hours exposure.
- Other effects:
- None
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
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