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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Non-GLP, near guideline study, available as unpublished report, limitations in design and/or reporting but otherwise adequate for assessment.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1971
Report date:
1971

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
yes
Remarks:
, 7 day observation period instead of 14
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Anthranilamide
EC Number:
201-851-2
EC Name:
Anthranilamide
Cas Number:
88-68-6
Molecular formula:
C7H8N2O
IUPAC Name:
2-aminobenzamide
Details on test material:
- Name of the test substance used in the study report: Anthranilsaeureamid

Test animals

Species:
rat
Strain:
other: Gassner rats
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
CMC (carboxymethyl cellulose)
Details on oral exposure:
- The test concentration used was 20% (w/v) in aqueous suspension with CMC.
Doses:
1000, 1250, 1600, 2000, 2500, 3200 and 4000 mg/kg
No. of animals per sex per dose:
10
Control animals:
no
Details on study design:
- Duration of observation period following administration: 7 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, macroscopic examination.

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
ca. 2 200 mg/kg bw
Based on:
test mat.
Mortality:
- 1000 mg/kg bw:: No mortality occured
- 1250 mg/kg bw.: 1 male animal died within 24 h. No aditional mortality occured.
- 1600 mg/kg bw:: 1 female animal died within 24 h. No aditional mortality occured.
- 2000 mg/kg bw:: 2 male and 1 female animals died within 24 h. No aditional mortality occured.
- 2500 mg/kg bw:: 8 male and 7 female animals died within 24 h. One aditional female animal died within 48 h.
- 3200 mg/kg bw:: All male (10) and 8 female animals died within 24 h. One aditional female animal died within 7 days.
- 4000 mg/kg bw: All male (10) and all female (10) animals died within 24 h.
Clinical signs:
other: Dyspnea, apathy, and lying in the abdominal and lateral position was observed.
Gross pathology:
Acute dilatation of the heart and congestive hyperemia of lung and liver was observed.

Applicant's summary and conclusion

Interpretation of results:
sligthly toxic
Remarks:
Migrated information