Registration Dossier
Registration Dossier
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EC number: 201-851-2 | CAS number: 88-68-6
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- GLP compliance:
- no
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- Anthranilamide
- EC Number:
- 201-851-2
- EC Name:
- Anthranilamide
- Cas Number:
- 88-68-6
- Molecular formula:
- C7H8N2O
- IUPAC Name:
- 2-aminobenzamide
- Test material form:
- solid
Constituent 1
Study design
- Analytical method:
- gas chromatography
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- 0.34
- Temp.:
- 25 °C
- pH:
- >= 7.85 - <= 8.1
Any other information on results incl. tables
Results
1st determination
20.9199 g 1 -octanol (water saturated)
0.0177 g anthranilamide (AA)
25.4937 water (octanol saturated)
| 1st determination | 2nd determination | 3rd determination | mean | std. dev. | |
| concentration of AA in the 1 -octanol phase (g/l) | 0.452 | 0.456 | 0.454 | 0.454 | 0.002 |
| concentration of AA in the water phase (g/l) | 0.181 | 0.188 | 0.193 | 0.187 | 0.006 |
Pow = c (AA; octanol) / c(AA, water) = 0.454 g/l / 0.187 g/l = 2.43
pH of the water phase: 7.85
2nd determination
20.9566 g 1 -octanol (water saturated)
0.0481 g AA
25.1420 g water (octanol saturated)
| 1st determination | 2nd determination | 3rd determination | mean | std. dev. | |
| concentration of AA in the 1 -octanol phase (g/l) | 1.322 | 1.326 | 1.332 | 1.327 | 0.005 |
| concentration of AA in the water phase (g/l) | 0.605 | 0.608 | 0.615 | 0.609 | 0.006 |
Pow = 2.18
pH of the water phase: 8.0
3rd determination
20.9250 g 1 -octanol (water saturated)
0.0993 g AA
25.7278 g water (octanol saturated)
| 1st determination | 2nd determination | 3rd determination | mean | std. dev. | |
| concentration of AA in the 1 -octanol phase (g/l) | 2.790 | 2.796 | 2.803 | 2.796 | 0.007 |
| concentration of AA in the water phase (g/l) | 1.357 | 1.385 | 1.453 | 1.392 | 0.040 |
Pow = 2.01
pH of the water phase: 8.1
Conclusion
| Pow | log Pow | |
| 1st determination | 2.43 | 0.39 |
| 2nd determination | 2.18 | 0.34 |
| 3rd determination | 2.01 | 0.30 |
| mean | 2.21 | 0.34 |
Applicant's summary and conclusion
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