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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
from 2017-11-07 to 2017-11-09
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
yes
Remarks:
see 'Principles of method if other than guideline'
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
yes
Remarks:
see 'Principles of method if other than guideline'
Qualifier:
according to
Guideline:
EPA OPPTS 830.7840 (Water Solubility)
Deviations:
yes
Remarks:
see 'Principles of method if other than guideline'
Principles of method if other than guideline:
A miscibility test was carried out to evaluate the solubility of Test Item in water. This procedure deviates from the guideline but is considered scientifically valid.
GLP compliance:
yes (incl. certificate)
Type of method:
other: miscibility test with visual inspection
Key result
Temp.:
20 °C
pH:
>= 11.63 - <= 13.05
Remarks on result:
completely miscible
Details on results:
The test item is miscible with water at room temperature.

Water solubility test

Test Item, (g)

Water, (g)

Observation

pH value

0.9563

8.54940

clear, homogeneous single-phase liquid

11.63

0.9599

8.55761

clear, homogeneous single-phase liquid

11.67

0.9476

0.95988

clear, homogeneous single-phase liquid

12.37

0.9557

0.94797

clear, homogeneous single-phase liquid

12.27

4.1967

0.50012

clear, homogeneous single-phase liquid

13.02

4.2163

0.47683

clear, homogeneous single-phase liquid

13.05

Conclusions:
The test item is miscible with water at room temperature.
Executive summary:

The water solubility was determined according to OECD 105, Regulation (EC) No. 440/2008 method A.6 and OPPTS 830.7840. In a preliminary test no saturated solution of the test item could not be prepared, therefore, the standard methods for determination of the water solubility are not feasible. Therefore, the water solubility of the test item was determined using the miscibility test with visual inspection.The test item was mixed with water in the following ratios: Test Item : Water = 1 : 9, 9 : 1, 1 : 1 (by weight). Miscibility was checked visually after vigorous shaking.The test item is miscible with water at room temperature (pH 11 - 13).

Description of key information

The test item is miscible with water at room temperature.

Key value for chemical safety assessment

Additional information

The water solubility was determined according to OECD 105, Regulation (EC) No. 440/2008 method A.6 and OPPTS 830.7840. In a preliminary test no saturated solution of the test item could not be prepared, therefore, the standard methods for determination of the water solubility are not feasible. Therefore, the water solubility of the test item was determined using the miscibility test with visual inspection. The test item was mixed with water in the following ratios: Test Item : Water = 1 : 9, 9 : 1, 1 : 1 (by weight). Miscibility was checked visually after vigorous shaking. The test item is miscible with water at room temperature (pH 11 - 13).