Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 259-709-0 | CAS number: 55566-30-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- January 1989
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study, performed according to standard method.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-5 (Acute Dermal Irritation)
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPPTS 870.2500 (Acute Dermal Irritation)
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Tetrakis(hydroxymethyl)phosphonium sulphate(2:1)
- EC Number:
- 259-709-0
- EC Name:
- Tetrakis(hydroxymethyl)phosphonium sulphate(2:1)
- Cas Number:
- 55566-30-8
- Molecular formula:
- C4H12O4P.1/2O4S
- IUPAC Name:
- tetrakis(hydroxymethyl)phosphonium sulphate(2:1)
- Test material form:
- other: liquid stored in the dark
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Froxfield Farms, UK
- Age at study initiation: 10-13 weeks old
- Weight at study initiation: 2.3-3.0 kg
- Housing: individually housed in metal cages
- Diet / water: free access to tap water and SDS Standard Rabbit Diet.
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature: 19°C
- Humidity 30-70 %
- Air changes: 19 per hour
- Photoperiod: 12 hr dark / 12 hr artificial light
IN-LIFE DATES: From 24 to 27 january 1989
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- undiluted, 0.5 mL/rabbit (expressed as active substance) that is a dose of 0.2 mL/cm².
- Duration of treatment / exposure:
- 4 hour(s)
- Observation period:
- 14 days
- Number of animals:
- 6 (4 males and 2 females)
- Details on study design:
- TEST SITE
- Area of exposure: Dorsal area of the trunk
- % coverage: approximately 10 cm2
- Type of wrap if used: 2.5 cm² gauze maintained in contact with the skin with elastic adhesive dressing.
REMOVAL OF TEST SUBSTANCE
- Washing: with water
- Time after start of exposure: 4h
SCORING SYSTEM: Erythema and oedema formations were both scored from 0 (no reaction) to 4 (severe reaction). Draize scores.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritant / corrosive response data:
- Throughout the observation period of 14 days of observation, no dermal response (erythema, oedema) was seen in any treated animal.
- Other effects:
- Throughout the observation period of 14 days of observation, no clinical signs was seen in any treated animal.
Any other information on results incl. tables
Table 8.1.1: Skin irritation data
Volume applied (mL) |
Sex |
Number of treated animals |
Erythema (E) / Oedema (O) |
Mean scores |
|||||
Day 1* |
Day 2 |
Day 3 |
Day 4 |
||||||
0.5 |
M |
4 |
E |
0 |
0 |
0 |
0 |
||
O |
0 |
0 |
0 |
0 |
|||||
F |
2 |
E |
0 |
0 |
0 |
0 |
|||
O |
0 |
0 |
0 |
0 |
|||||
* Approximately 30 minutes after removal of the dressing
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the test conditions of this study, the active substance THPS 75% was considered as not irritating to skin and not classified according to EU criteria.
- Executive summary:
In a primary dermal irritation study performed according to the US EPA Pesticide Assessment Guidelines, Subdivision F, § 81-5 in compliance with the EPA OPPTS 870.2500, OECD 404 guidelines and in compliance with GLP, six animals (4 males and 2 females) were dermally exposed to 0.5mL of THPS at 75% in water for 4 hours under a semi-occlusive dressing.
Cutaneous reactions were observed approximately 24, 48 and 72 hours after removal of the dressing and then daily until day 14. The mean values of the scores for erythema and oedema were calculated for each animal.
No dermal irritation was elicited by product application throughout the observation period in any animal. The scores for both erythema and oedema are 0 for all animals.The active substance seems not to be irritant or corrosive via skin exposure.
Under the test conditions of this study, the active substance THPS 75% was considered as not irritating to skin and not classified according to the criteria of the CLP Regulation (EC) N°1272/2008.
This skin irritation study is classified as acceptable. It satisfies the guideline requirement for a skin irritation in the rabbit.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
