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Administrative data

Link to relevant study record(s)

Description of key information

Following a single administration of THPS by the oral route, approximately 90% is absorbed.

Excretion is principally via the urine, faeces and exhaled air.

The principal metabolites are considered to be THPO and formaldehyde (three studies are available, Kr.2).
Dermal absorption is relatively low and is dependent upon concentration, being 1.3% for the concentrate and 4.8% for the 10% dilution (one study was available, Kr. 1)
The rapid excretion of THPS and its lack of potential for bioaccumulation indicate that acute data are sufficient to predict toxicokinetics on repeated exposure (waiving was proposed for repeated exposure).

Key value for chemical safety assessment

Bioaccumulation potential:
low bioaccumulation potential
Absorption rate - oral (%):
90
Absorption rate - dermal (%):
4.8

Additional information