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EC number: 259-709-0 | CAS number: 55566-30-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
EPA OPP 72-1, OECD Guideline 203, GLP, key study, validity 1:
96h-LC50 (Oncorhynchus mykiss) = 71 mg/L (measured, as main ingredient).
THPS is considered as harmful to fish.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 71 mg/L
Marine water fish
Marine water fish
- Effect concentration:
- 65 mg/L
Additional information
Six studies are available to assess the short-term toxicity of the active substance THPS to fish. These studies were performed with 75% THPS aqueous solution under semi-static or flow-through conditions, with freshwater and seawater species. The results were expressed in test item concentrations and converted in active ingredient (100% THPS).
There are two studies of reliability 1 (Jenkins, 1991a; Jenkins, 1991b) and two studies of reliabiity 3 on freshwater species (Hill, 1984b; Douglas, 1987); one study of reliability 1 on a brackish species (Boeri, 1995a) and one study of reliability 2 on a marine water species (Douglas, 1989). Whatever the test conditions, the valid studies (of reliability 1 or 2) show 96 h-LC50 values ranging between 65 (brackish species) and 74 mg a.i./L (freshwater species). The valid study with the lowest LC50 value has been defined as the key study (Jenkins, 1991a).
Results are expressed in the table below (as main ingredient):
Test method |
Species |
Endpoint / Type of test |
Exposure |
Reliability |
Flag |
Results (LC50 (95% CL), mg/L) |
Reference |
EPA OPP 72-1 and OECD Guideline 203 |
Oncorhynchus mykiss (freshwater species) |
Mortality / Acute |
Semi-static, 96h |
1 |
KS |
71 (58-105) |
Jenkins, 1991a |
EPA OPP 72-1 and OECD Guideline 203 |
Lepomis macrochirus (freshwater species) |
Mortality / Acute |
Semi-static, 96h |
1 |
SS |
74 (51-157) |
Jenkins, 1991b |
EPA OPP 72-3 and OECD Guideline 203 |
Cyprinodon variegatus (brackish species) |
Mortality / Acute |
Flow through, 96h |
1 |
SS |
72 (41-110) |
Boeri, 1995a |
Ministry of Agriculture, Fisheries and Food, UK |
Pleuronectes platessa (marine species) |
Mortality / Acute |
Semi-static, 96h |
2 |
SS |
65 (56-75) |
Douglas, 1989 |
No guideline but similar to OECD Guideline 203 |
Oncorhynchus mykiss (freshwater species) |
Mortality / Acute |
Flow through, 96h |
3 |
SS |
74 (66-85) |
Hill, 1984b |
OECD Guideline 203 |
Lepomis macrochirus (freshwater species) |
Mortality / Acute |
Flow through, 96h |
3 |
SS |
14 (11-18) |
Douglas, 1987 |
In conclusion, THPS is considered harmful to fish.
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