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Ecotoxicological information

Short-term toxicity to fish

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Link to relevant study record(s)

Description of key information

EPA OPP 72-1, OECD Guideline 203, GLP, key study, validity 1:
96h-LC50 (Oncorhynchus mykiss) = 71 mg/L (measured, as main ingredient).
THPS is considered as harmful to fish.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
71 mg/L

Marine water fish

Marine water fish
Effect concentration:
65 mg/L

Additional information

Six studies are available to assess the short-term toxicity of the active substance THPS to fish. These studies were performed with 75% THPS aqueous solution under semi-static or flow-through conditions, with freshwater and seawater species. The results were expressed in test item concentrations and converted in active ingredient (100% THPS).

There are two studies of reliability 1 (Jenkins, 1991a; Jenkins, 1991b) and two studies of reliabiity 3 on freshwater species (Hill, 1984b; Douglas, 1987); one study of reliability 1 on a brackish species (Boeri, 1995a) and one study of reliability 2 on a marine water species (Douglas, 1989). Whatever the test conditions, the valid studies (of reliability 1 or 2) show 96 h-LC50 values ranging between 65 (brackish species) and 74 mg a.i./L (freshwater species). The valid study with the lowest LC50 value has been defined as the key study (Jenkins, 1991a).

Results are expressed in the table below (as main ingredient):

Test method

Species

Endpoint / Type of test

Exposure

Reliability

Flag

Results (LC50 (95% CL), mg/L)

Reference

EPA OPP 72-1 and OECD Guideline 203

Oncorhynchus mykiss (freshwater species)

Mortality / Acute

Semi-static, 96h

1

KS

71 (58-105)

Jenkins, 1991a

EPA OPP 72-1 and OECD Guideline 203

Lepomis macrochirus (freshwater species)

Mortality / Acute

Semi-static, 96h

1

SS

74 (51-157)

Jenkins, 1991b

EPA OPP 72-3 and OECD Guideline 203

Cyprinodon variegatus (brackish species)

Mortality / Acute

Flow through, 96h

1

SS

72 (41-110)

Boeri, 1995a

Ministry of Agriculture, Fisheries and Food, UK

Pleuronectes platessa (marine species)

Mortality / Acute

Semi-static, 96h

2

SS

65 (56-75)

Douglas, 1989

No guideline but similar to OECD Guideline 203

Oncorhynchus mykiss (freshwater species)

Mortality / Acute

Flow through, 96h

3

SS

74 (66-85)

Hill, 1984b

OECD Guideline 203

Lepomis macrochirus (freshwater species)

Mortality / Acute

Flow through, 96h

3

SS

14 (11-18)

Douglas, 1987

In conclusion, THPS is considered harmful to fish.