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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
Data is from secondary source

Data source

Reference
Reference Type:
secondary source
Title:
Reports of the Scientific Committee on Cosmetology (seventh series)
Author:
Commission of the European Communities
Year:
1988
Bibliographic source:
Directorate-General Environment, Consumer Protection and Nuclear Safety- Commission of the European Communities- Brussels Luxembourg, 1988.

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as below
Principles of method if other than guideline:
Acute oral toxicity in rat by using (4-(4-aminophenyl)(4-iminocyclohexa-2,5-dienylidene)methyl)-2-methylaniline hydrochloride
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
SMILES:CC1=CC(=C(c2ccc(N)cc2)c2ccc(N)cc2)C=CC1=N_Cl
Specific details on test material used for the study:
- Name of test material (as cited in study report): 4,4',4"-triamino-3-methyl-triphenyl carbenium chloride
- Molecular formula (if other than submission substance): C16H12N2O4S.Na
- Molecular weight (if other than submission substance): 350.3289 g/mole
- Substance type: Organic

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
CMC (carboxymethyl cellulose)
Remarks:
as 40% suspension
Details on oral exposure:
DOSAGE PREPARATION (if unusual): Prepared as a 40% suspension in CMC (carboxymethyl cellulose).
Doses:
12000 mg/kg bw
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 12 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50 % mortality observed
Mortality:
No mortality was observed at 12000 mg/kg bw
Clinical signs:
not specified
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
LD50 was considered to be >12000 mg/kg bw, when rats were treated with (4-(4-aminophenyl)(4-iminocyclohexa-2,5-dienylidene)methyl)-2-methylaniline hydrochloride orally.
Executive summary:

In acute oral toxicity study, rat were treated with (4-(4-aminophenyl)(4-iminocyclohexa-2,5-dienylidene)methyl)-2-methylaniline hydrochloride at the concentration of 12000 mg/kg bw orally as a 40% suspension in carboxymethylcellulose.No mortality was observed at 12000 mg/kg bw in treated rats. Therefore, LD50 was considered to be > 12000 mg/kg when rats were treated with 4-(4-aminophenyl)(4-iminocyclohexa-2,5-dienylidene)methyl)-2-methylaniline hydrochloride) orally.