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EC number: 206-329-8 | CAS number: 328-42-7
The acute skin irritation study of the test item was performed in New Zealand White rabbits. The irritation effects of the test item were evaluated according to the Draize method (OECD No.: 404, 2002).
The study consisted of initial and confirmatory test. The initial test was needed, because the substance was suspected to have corrosion potential on the basis of pH value (1.76). In initial test, three patches were applied sequentially to the hairless skin of one experimental animal. The dose was 0.5 g per patches.
In confirmatory test, the test item was administered in pure state, in a single dose of 0.5 g to the hairless skin of all experimental rabbits. The untreated skin of each animal served as control.
After each patch removal, the rest of the test item was removed with water of body temperature.
The irritation symptoms were examined at 1, 24, 48 and 72 hours then one and two weeks after the patch removal in first animal and at 1, 24, 48 and 72 hours after the patch removal in second and third animals. For the initial test, in the first animal the test site was also examined after the treatment (3 min., 1 and 4 hours exposition time).
In the initial test very slight erythema was observed in first animal after 1 hour exposition. Well defined erythema appeared in same animal after 4 hours exposition. Since corrosive effect was not found in the initial test, two additional animals were treated with one patch, for an exposure period of four hours.
One hour after the patch removal, very slight erythema occurred in two animals. Well defined erythema was observed in first animal.
24 hours after the patch removal all animals were symptom-free.
72 hours after the treatment the confirmatory study was terminated, since there were no primary irritation symptoms. The observation of the first animal continued for two weeks.
2 weeks after the patch removal the initial test was terminated, since there were no any primary irritation symptoms.
The animals' individual mean scores (considering readings at 24, 48 and 72 hours after patch removal) for erythema and oedema were 0.00, 0.00 and 0.00 respectively.
During the study the behaviour and general state of animals were normal.
There were no notable body weight changes during the contact and observation period.
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