Decanedioic acid, compound with ethanolamine / Decanedioic acid, compound with 2-aminoethanol

Melting point / freezing point

Administrative data

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

from 12 June 2017 to 27 July 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2017

Report date:

2017

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

Version / remarks:

2008

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Version / remarks:

1995

Deviations:

no

Test guideline 3

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7200 (Melting Point / Melting Range)

Version / remarks:

1998

Deviations:

no

GLP compliance:

yes

Type of method:

differential scanning calorimetry

Test material

Test material information

Constituent 1

Reference substance name:

Sebacic acid, compound with 2-aminoethanol (1:2)

Molecular formula:

C10H18O4.2(C2H7NO)

IUPAC Name:

Sebacic acid, compound with 2-aminoethanol (1:2)

Test material form:

solid: particulate/powder

Details on test material:

Physical appearance: Off-white to pale yellow powder
Storage conditions: At room temperature

Results and discussion

Melting / freezing point

Key result

Melting / freezing pt.:

58.8 °C

Decomposition:

yes

Decomp. temp.:

125 °C

Any other information on results incl. tables

DSC EXPERIMENT 1

Endothermic peak between 25°C and 75°C. The extrapolated onset temperature of the peak could not be determined since it was observed within 2 minutes from the start of the experiment. The endothermic effect was most likely obtained due to melting of the test item. The second endothermic effect (from 125°C) was probably obtained due to reaction and/or decomposition of the test item. After the experiment, an off white molten residue remained in the sample container. 

DSC EXPERIMENT 2

In order to rule out degradation during melting, Experiment 2 was stopped directly after the melting peak. A small endothermic peak was observed between -25°C and 0°C; probably caused by restructuration of the test item. The extrapolated onset temperature of the second endothermic peak was 59.002°C. After the experiment, a colourless molten residue remained in the sample container (original colour: off-white to pale yellow). It demonstrated that melting was the reason for the endothermic effect at 59.002°C. The difference in residue colour compared to Experiment 1 indicated that reaction and/or decomposition caused the endothermic effect from 125°C on in Experiment 1.

DSC EXPERIMENT 3

The extrapolated onset of the melting peak was 58.532°C. After the experiment, a colourless molten residue remained in the sample container. 

DATA HANDLING

The mean of Experiment 2 (59.002°C) and Experiment 3 (58.532°C) was reported as the melting point of the substance.

 

Applicant's summary and conclusion

Conclusions:

The melting temperature of the substance was determined to be 58.8°C.

Executive summary:

Differential Scanning Calorimetry (DSC) experiments were performed in a GLP study according to EC A.1, OECD 102 and OPPTS 830.7200.

The melting temperature of the substance was determined in duplicate obtaining a mean value of 58.8°C. Reaction and/or decomposition of the substance was observed at temperatures from 125°C.

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