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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1963
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1963
Report date:
1963

Materials and methods

Principles of method if other than guideline:
Groups of 10 male NMRI mice were administered the test substance diluted in water at concentrations of 800 to 4200 mg/kg bw. Animals were then observed for clinical signs and mortality.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
N,N-bis(2-hydroxyethyl)undec-10-enamide
EC Number:
262-114-9
EC Name:
N,N-bis(2-hydroxyethyl)undec-10-enamide
Cas Number:
60239-68-1
Molecular formula:
C15H29NO3
IUPAC Name:
N,N-bis(2-hydroxyethyl)undec-10-enamide
Test material form:
not specified

Test animals

Species:
mouse
Strain:
NMRI
Sex:
male
Details on test animals or test system and environmental conditions:
Body weight: ca. 20 g

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Doses:
From 0 to 4200 mg/kg bw
No. of animals per sex per dose:
10
Control animals:
no
Details on study design:
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs
Statistics:
None

Results and discussion

Effect levels
Key result
Sex:
male
Dose descriptor:
LD50
Effect level:
ca. 2 700 mg/kg bw
Based on:
test mat.
Mortality:
As of 2000 mg/kg bw
Clinical signs:
Lying on the side or the back, cramps, uneven breathing, no reaction to noise or other stimulations.
Mortality was observed from 0.5 to 4 h after exposure.
Body weight:
Not evaluated.
Gross pathology:
Not evaluated.
Other findings:
Not evaluated.

Any other information on results incl. tables

None.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
Under the study conditions, the LD50 of the test substance in mouse was determined to be 2700 mg/kg bw.
Executive summary:

A study was conducted to determine the oral acute toxicity of the test substance, C11-unsatd. DEA (purity not specified). Groups of 10 male NMRI mice received a single dose of the test substance diluted in water by gavage at concentrations ranging from 800 to 4200 mg/kg bw. The animals were then observed for clinical signs and mortality. Under the study conditions, the LD50 of the test substance in mice was determined to be 2700 mg/kg bw (Ihlow, 1963).