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Partition coefficient

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partition coefficient
Data waiving:
study technically not feasible
Justification for data waiving:
the study does not need to be conducted because the substance has a high surface activity
partition coefficient
Type of information:
calculation (if not (Q)SAR)
Migrated phrase: estimated by calculation
Adequacy of study:
key study
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Principles of method if other than guideline:
EPI Suite Calculation
GLP compliance:
Type of method:
other: Calculation
Partition coefficient type:
Key result
log Pow
Partition coefficient:
25 °C
ca. 7

Description of key information

End point waived as testing scientifically not feasible due to surface active properties of the substance.  EPISuite calculated Log Kow value of 0.832 is used for CSA purposes only

Key value for chemical safety assessment

Log Kow (Log Pow):
at the temperature of:
25 °C

Additional information

Sodium Lauryl Methyl Isethionate (SLMI) is an Anionic Surface Acting Agent. This therefore affects the results of the Octanol-Water Partition Coefficient test, due to the emulsion that forms at the partition interface. Surface acting agents have the ability of altering the surface or interfacial energies of two immiscible phases, thus skewing the results of testing.

According to OECD Testing Guidelines for Test Method 117 Partition Coefficient (n-octanol/water), High Performance Liquid Chromatography Method isn’t applicable for surface-active agents.

According to OECD Testing Guidelines for Test Method 107, the Shake Flask method is impossible to use with surface-active agents.

According to OECD Testing Guidelines for Test Method 123, Partition Coefficient (1-Octanol/Water), Slow Stirring method is not applicable for substances that display significant interfacial activity. So, as with the Shake Flask method and due to the properties of SLMI, coupled with its foaming capabilities it would impossible to separate the two immiscible solvents at the interface to obtain reliable results.