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Toxicological information

Sensitisation data (human)

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Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Justification for type of information:
Alpha-terpineol is one of the main constituents of multiconstituent substance TERPINEOL MULTICONSTITUENT. Therefore, data on alpha-terpineol can be used for extrapolation to TERPINEOL MULTICONSTITUENT.
Cross-reference
Reason / purpose:
read-across source

Data source

Materials and methods

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Type:
Constituent
Test material form:
liquid

Results and discussion

Results of examinations:
SYMPTOMS
- Frequency, level, duration of symptoms observed:

NO. OF PERSONS WITH/OUT REACTIONS COMPARED TO STUDY POPULATION
- Number of subjects with positive reactions: 2 over 1200 patients
- Number of subjects with equivocal reactions: 0
- Number of subjects with irritating reactions: no data

RESULT OF CASE REPORT:

Any other information on results incl. tables

No data

Applicant's summary and conclusion

Conclusions:
In the first group of patients, there were positive reactions to perfume mix in 63 patients (5.2%). The incidence of positivity to individual fragrances gave positive results on 2 patients out of 1200 patients tested for alpha terpineol at concentration up to 5% in petrolatum.
Executive summary:

One group of patients (1200) was patch tested with different concentrations of perfume mix and fragrance raw materials. The study was to evaluate the incidence of contact dermatitis to fragrances in Roma, Italy, and the influence of limited variations in fragrance and perfume mix concentrations on patch test responses.

The results showed that alpha terpineol at concentration of 5% gave positive results on 2 patients over 1200.