Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Adsorption / desorption
Administrative data
Link to relevant study record(s)
Description of key information
The test substance eluted as three peaks and the corresponding Log Koc for the test substance by UV ranged from unretained (< urea) to 4.43 (OECD 117 and EU Method C.19).
Key value for chemical safety assessment
- Koc at 20 °C:
- 26 915
Additional information
GUIDELINE
The study was based on procedures in the OECD Guideline for the Testing of Chemicals, 121,Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using,High Performance Liquid Chromatography (HPLC)and Official Journal of the European Communities No. L225 Method C.19: Estimation of the Adsorption Coefficient on Soil and Sewage Sludge using High Performance Liquid Chromatography (HPLC).
METHODS
Five calibration standards of known log Koc were prepared from reference materials in the respective mobile phase at a nominal concentration range (10.0 to 200 mg/L) selected to provide desired ultraviolet (UV) detector response. Capacity factors were calculated for the five calibration standards using a sixth calibration standard, urea, to estimate the column dead time (i.e. the retention time of an unretained organic compound). The logarithms of the capacity factors were then plotted against published log Koc values for the five calibration standards with known log Koc to establish a linear regression equation.
Test substance solutions were prepared at nominal concentrations of 1.00 mg/mL and 5.00 mg/mL in 55% methanol (MeOH): 45% HPLC-grade reagent water (H2O). The calibration standard preparations were sequentially injected into the HPLC system followed by a single injection of the matrix blank preparation, single injections of each of the three 1.00 mg/mL test substance preparations, and a single injection of the 5.00 mg/mL test substance preparation. The calibration standards injection sequence was repeated following the test substance injections. The HPLC system was operated under standardised isocratic, reverse-phase operating conditions per the guideline.
RESULTS
Under the chromatographic conditions specified, the test substance eluted as three peaks on the ELSD. The corresponding Log Koc for the test substance by UV ranged from unretained (< urea) to 4.43.
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