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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
16.05-20.05.2003
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient - HPLC Method)
Version / remarks:
92/69/EWG
Deviations:
no
GLP compliance:
yes
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
4.9
Temp.:
25 °C
pH:
7
Conclusions:
The test item has a log Pow of 4.9.
Executive summary:

A study was conducted in accordance with 92/69/EWG method A.8 to determine the partition coefficient of the test substance. A preliminary Log Pow was calculated showing the HPLC method was suitable.

As eluent a micture of methanol / distilled water 75:25 % (v/v) was chosen. A linear regression graph was determined and decimal logarithms of the capacity factors k were calculated. The linear regression parameters of the relationship log Pow = f(log k) were also calculated from the data obtained with the calibration mixture.The log Pow of the test substance was determined from its measured capacity factor. The logPow of the test item was determined to be 4.9.

Description of key information

The logPow of the test item was determined to be 4.9.

Key value for chemical safety assessment

Log Kow (Log Pow):
4.9
at the temperature of:
25 °C

Additional information

A study was conducted in accordance with 92/69/EWG method A.8 to determine the partition coefficient of the test substance. A preliminary Log Pow was calculated showing the HPLC method was suitable.

As eluent a micture of methanol / distilled water 75:25 % (v/v) was chosen. A linear regression graph was determined and decimal logarithms of the capacity factors k were calculated. The linear regression parameters of the relationship log Pow = f(log k) were also calculated from the data obtained with the calibration mixture.The log Pow of the test substance was determined from its measured capacity factor. The logPow of the test item was determined to be 4.9.