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EC number: 220-474-4
CAS number: 2778-42-9
study was performed to assess the hydrolytic stability of the test
substance according to OECD Guideline 111, in compliance with GLP. Based
on the results of a preliminary study, the test was conducted at pH 4, 7
and 9 at 25 ± 0.5°C, and at pH 1.2 at 37 ± 0.5°C for 24 h. Under the
study conditions, rate constant and estimated half-life were found to be
1.692 h-1 and 0.410 h (at pH 4), 1.9044 h-1 and 0.364 h (at pH 7), and
2.0664 h-1 and 0.336 h (at pH 9), respectively. Under physiologically
important conditions (pH 1.2, 37°C), the test substance was found to
degrade almost instantaneously in the media, with only 3.45% of the
fortified concentration remaining at the time zero initial analysis
(Woolley and Mullee, 2003).
hydrolysis products of m-TMXDI are comparable to those of other
aliphatic and aromatic diisocyanates. Under environmentally relevant
conditions (i.e. low concentrations of m-TMXDI, pH = 7), an insoluble urea
and possibly also polyurea are
formed (Allnex, pers. comm.; Pemberton and Tury, 2004;
Heimbachet al., 1996; Yakabeet al., 1999; Turyet al.,
2003; cited in Environment Canada/Health Canada, 2008).
In specific cases (i.e. high dispersion combined with low
concentrations), tetramethyl-m-xylene diamine may also be
produced (Sopac and Boltromejuk, 1974; cited in Environment
Canada/Health Canada, 2008).
structure of the urea and polyurea are presented in Figure 1.
of the urea and possible polyurea formed by hydrolysis of m-TMXDI
under environmentally relevant conditions
structure of tetramethyl-m-xylene diamine is presented in Figure 2.
of tetramethyl-m-xylene diamine potentially formed by hydrolysis of
m-TMXDI under specific conditions (i.e. high dispersion combined with
Canada/Health(2008). Screening assessment for the challenge. Benzene,
diisocyanate). Chemical Abstracts Service Registry Number 2778-42-9.https://www.ec.gc.ca/ese-ees/9C2F9934-38D3-4940-A472-5DD238B6076D/batch2_2778-42-9_en.pdf.
F, Jaeger K and Sporenberg W (1996).Fate
and biological effects of polymeric MDI (4,4-diphenylmethane
diisocyanate and homologues) in small artificial ponds. Ecotox Environ.
D and Tury B (2004). TDI industry risk assessment: sections on
physico-chemical properties, environmental exposures and environmental
effects. GIL report 2004/E.
ED and Boltromejuk LP (1974). Gig. Sanit. 7:10-13.
B, Pemberton D and Bailey RE (2003). Fate and potential environmental
effects of methylenediphenyl diisocyanate and toluene diisocyanate
released into the atmosphere. J. Air and Waste Manage. Assoc. 53:61-66.
Y, Henderson KM, Thompson WCet al.(1999). Fate of
methylenediphenyl diisocyanate and toluene diisocyanate in the aquatic
environment. Environ. Sci. Technol. 33(15):2579-2583.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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