Disodium tartrate

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

17 November - 11 December 2015

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Version / remarks:

Adoptation 2014

Deviations:

no

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

GLP compliance:

no

Type of method:

flask method

Specific details on test material used for the study:

Storage conditions: ambient temperature (10 to 30 °C)

Key result

Water solubility:

500 g/L

Conc. based on:

element (dissolved fraction)

Temp.:

20 °C

pH:

>= 6.9 - <= 7.1

Table 1: Results of the preliminary visual estimation of the water solubility

 

Amount of test item / mg	Added volume ofdist. water / mL	Total volume / mL	Appearance of mixture
100.2	0.1	0.1	Not dissolved
	0.4	0.5	Dissolved

According to this preliminary visual estimation the water solubility of the test item was > 200 g/L but

<1002 g/L. Therefore the preferred method for the main test was the flask method. Due to this high presumed water solubility an additional stirring test was performed prior to the performance of the main test to determine the highest amount of test item that can still be stirred sufficiently in a mixture with water (see Table 2).

Table 2: Stirring test

Amount of test item/g   Added volume of dist. water /mL  Total volume /mL  Observation  10.36  4  4  could not be stirred  10.36  2  6     could not be stirred  10.36  0.5  6.5     could not be stirred  10.36  0.5  7     could be stirred

According to the stirring test, mixtures of approx. 1480 g/L test item in dist.water were used in the main test.

 

Flask method

The data for the evaluation are given in Table 3. After the equilibration time a small amount of precipitate was observed in the flasks of the experiments excluding in the blank experiment. The water solubility was calculated from the measured and unrounded concentration values and not from the rounded values given in Table 3.

Table 3: Water solubility experiments of the test item

Experiment	24 h experiment	48 h experiment	72 h experiment	Blank experiment (72 h)
Amount of test itemIg	15.5^1^)	14.7	14.8	--
Amount of distilled water/ mL	10	10	10	10
Stirring time at 30 °C / h	24	48	72	72
pH at 23 °C	6.9	7.1	7.0	6.7
Measured concentration sodium/ g/L	100	100	100	0.009
Water solubility / g/L	500	500	500	<0.01

1) Dried test item, no influence on the results

The water solubility of the test item at 20 °C was determined to be C_s = 500 g/L.

Description of key information

500 g/L at 20 °C and pH 7.1 (OECD 105, flask method)

Key value for chemical safety assessment

Water solubility:

500 g/L

at the temperature of:

20 °C

Additional information

The water solubility of test substance is calculated based on the measured concentration of sodium.