Hydrogen bis[2-[[1-(3-chlorophenyl)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-4-yl]azo]-5-sulphamoylbenzoato(2-)]chromate(1-)

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

secondary literature

Justification for type of information:

Data is from safety assessment report.

Data source

Reference

Reference Type:

other: secondary source

Title:

To evaluate skin irritation potential of the given test chemical.

Author:

European Commission (EC) - Scientific Committee on Cosmetology (SCC)

Year:

1988

Bibliographic source:

European Commission (EC) - Scientific Committee on Cosmetology (SCC),1988

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

To evaluate ocular irritation potential of test chemical on guinea pig eye.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Hydrogen bis[2-[(4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)azo]benzoato(2-)]chromate(1-)

EC Number:

227-022-5

EC Name:

Hydrogen bis[2-[(4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)azo]benzoato(2-)]chromate(1-)

Cas Number:

5601-29-6

Molecular formula:

C34H24CrN8O6.H

IUPAC Name:

Chromium(3+) ion hydrogen bis([(6E)-6-{2-[(4Z)-3-methyl-5-oxo-1-phenyl-4 ,5-dihydro-1H-pyrazol-4-ylidene]hydrazin-1 -ylidene}cyclohexa-2,4-dien-1- ylidene]methanebis(olate))

Details on test material:

IUPAC name: chromium(3+) ion hydrogen bis([(6E)-6-{2-[(4Z)-3-methyl-5-oxo-1-phenyl-4 ,5-dihydro-1H-pyrazol-4-ylidene]hydrazin-1 -ylidene}cyclohexa-2,4-dien-1- ylidene]methanebis(olate))
comman name:Acid yellow 121
Molecular formula :C34H24CrN8O6.H
Molecular weight :695.633 g/mol
Substance type:organic
Physical state:solid
Smiles:c12[N]3=N[C@@-]4C(N(N=C4C)c4ccccc4)=O[Cr+3]453([N](=N[C@@-]3C(N(N=C3C)c3ccccc3)=O5)c3c(C(=O)[O-]4)cccc3)[O-]C(c1cccc2)=O
InChI:1S/2C17H13N4O3.Cr/c2*1-11-15(16(22)21(20-11)12-7-3-2-4-8-12)19-18-14-10-6-5-9-13(14)17(23)24;/h2*2-10H,1H3,(H,23,24);/q2*-1;+3/p-1/b2*19-18+;

Test animals / tissue source

Species:

guinea pig

Strain:

not specified

Details on test animals or tissues and environmental conditions:

not specified

Test system

Vehicle:

other: Cremophor EL water mixture

Controls:

not specified

Amount / concentration applied:

0.1ml of 0.1%

Duration of treatment / exposure:

Not specified

Observation period (in vivo):

Not specified

Number of animals or in vitro replicates:

Not specified

Details on study design:

Not specified

Results and discussion

In vivo

Results

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

other: Not specified

Reversibility:

not specified

Remarks on result:

no indication of irritation

Irritant / corrosive response data:

No ocular irritation reactions were observed.

Other effects:

Not specified

Applicant's summary and conclusion

Interpretation of results:

other: Not irrtating

Conclusions:

No positive ocular irritation reactions were observed. Hence, the test chemical was considered to be not eye irritant to the rabbits’ eye.

Executive summary:

The eye irritation study of test chemical was conducted on guinea pigs to assess its eye irritation potential. About 0.1ml of 0.1% test chemical in a Cremophor EL/water mixture was instilled into the eyes of each rabbit. No positive ocular irritation reactions were observed. Hence, the test chemical was considered to be not eye irritant to the rabbits’ eye.