Registration Dossier
Registration Dossier
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EC number: 220-971-6 | CAS number: 2950-43-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from handbook.
Data source
Referenceopen allclose all
- Reference Type:
- other: authoritative database
- Title:
- Acute oral toxicity
- Author:
- U.S. National Library of Medicine
- Year:
- 2 017
- Bibliographic source:
- ChemIDplus, 2017
- Reference Type:
- other: authoritative database
- Title:
- Acute oral toxicity study in rat.
- Author:
- U.S. National Library of Medicine
- Year:
- 2 017
- Bibliographic source:
- HSDB
- Reference Type:
- review article or handbook
- Title:
- Acute oral toxicity LD50
- Author:
- Richard J. Lewis
- Year:
- 2 012
- Bibliographic source:
- Sax's Dangerous Properties of Industrial Materials, 12th Edition, 5 Volume Set, 2012.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute oral toxicity study of test chemical in rat.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Ammonium sulphamidate
- EC Number:
- 231-871-7
- EC Name:
- Ammonium sulphamidate
- Cas Number:
- 7773-06-0
- Molecular formula:
- H3NO3S.H3N
- IUPAC Name:
- Ammonium sulphamidate
- Details on test material:
- Name: Ammonium sulphamidate
InChI: 1S/H3NO3S.H3N/c1-5(2,3)4;/h(H3,1,2,3,4);1H3
Smiles: S(N)(=O)(=O)[O-].[NH4+]
Molecular formula :H6N2O3S
Molecular weight :114.124 g/mol
Substance type:Inorganic
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- not specified
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality was observed
- Mortality:
- 50% mortality was observed at 2000 mg/kg
- Clinical signs:
- other: not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- LD50 was considered to be 2000 mg/kg bw, when rats were treated with test chemical via oral route.
- Executive summary:
Acute oral toxicity study of test chemical was conducted in rat at the concentration of 2000 mg/kg bw. 50% mortality was observed at 2000 mg/kg bw. Therefore, LD50 was considered to be 2000 mg/kg bw, when rats were treated with test chemical via oral route.
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