Registration Dossier
Registration Dossier
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EC number: 228-630-3 | CAS number: 6310-09-4
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Remarks:
- In vivo study carried out before the ECHA requirement of in vitro studies for eye irritation!
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2008
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1-(5-chloro-2-thienyl)ethan-1-one
- EC Number:
- 228-630-3
- EC Name:
- 1-(5-chloro-2-thienyl)ethan-1-one
- Cas Number:
- 6310-09-4
- Molecular formula:
- C6H5ClOS
- IUPAC Name:
- 1-(5-chlorothiophen-2-yl)ethan-1-one
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Male
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Amount / concentration applied:
- 0.1 g / eye / rabbit
- Observation period (in vivo):
- 1 hour, 24, 48, 72 hours
- Number of animals or in vitro replicates:
- 3 male rabbits
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Time point:
- 24/48/72 h
- Score:
- 42.3
- Max. score:
- 42.3
Applicant's summary and conclusion
- Interpretation of results:
- Category 2A (irritating to eyes) based on GHS criteria
- Conclusions:
- H319 : Causes serious eye irritation
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