Registration Dossier
Registration Dossier
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EC number: 244-942-2 | CAS number: 22374-89-6
Endpoint summary
Administrative data
Description of key information
Skin Irritation:
The study need not be conducted because the substance is a strong acid (pH<=2.0) or strong base (pH=> 11.5). The experimental pH of 1-methyl-3-phenylpropylamine (CAS no.: 22374-89-6) was 11.6 Hence this endpoint was considered for waiver.
Eye Irritation:
The study need not be conducted because the substance is a strong acid (pH<=2.0) or strong base (pH=> 11.5). The experimental pH of 1-methyl-3-phenylpropylamine (CAS no.: 22374-89-6) was 11.6 Hence this endpoint was considered for waiver.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study need not be conducted because the substance is a strong acid (pH <= 2.0) or base (pH => 11.5)
- Justification for type of information:
- The study need not be conducted because the substance is a strong acid (pH<=2.0) or strong base (pH=> 11.5). The experimental pH of 1-methyl-3-phenylpropylamine (CAS no.: 22374-89-6) was 11.6. Hence this endpoint was considered for waiver
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study need not be conducted because the substance is a strong acid (pH <= 2.0) or base (pH => 11.5)
- Justification for type of information:
- The study need not be conducted because the substance is a strong acid (pH<=2.0) or strong base (pH=> 11.5). The experimental pH of 1-methyl-3-phenylpropylamine (CAS no.: 22374-89-6) was 11.6. Hence this endpoint was considered for waiver.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irreversible damage)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin Irritation:
The study need not be conducted because the substance is a strong acid (pH<=2.0) or strong base (pH=> 11.5). The experimental pH of 1-methyl-3-phenylpropylamine (CAS no.: 22374-89-6) was 11.6 Hence this endpoint was considered for waiver.
Eye Irritation:
The study need not be conducted because the substance is a strong acid (pH<=2.0) or strong base (pH=> 11.5). The experimental pH of 1-methyl-3-phenylpropylamine (CAS no.: 22374-89-6) was 11.6 Hence this endpoint was considered for waiver.
Justification for classification or non-classification
According to the CLP Regulation (EC n. 1272/2008) and based on the high pH of 1-methyl-3-phenylpropylamine (CAS no.: 22374-89-6) (pH= 11.6), the classificationSkin Corrosive 1B and Eye Damage 1 isproposed for 1-methyl-3-phenylpropylamine (CAS no.: 22374-89-6).
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