Registration Dossier
Registration Dossier
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EC number: 947-119-2 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Irritation data are based on structural analogues LiDNNSA, DNNSA and BaDNNSA
Skin irritation
Six rabbits were exposed to the test substance dermally for 24 hours under occlusion (PSL 1981 (1), PSL 1981 (2)). The test substance initiated irritation of the skin at 24 and 72 h observations. This irritation was not shown to be reversible. Therefore the test substance is classified as skin irritant category 2.
Eye irritation
Six rabbits were treated with the test substance in an eye irritation test (PSL 1981 (1), PSL 1981 (2)). During the observation period of 72 hours severe eye irritation was reported (including effects on cornea), which was not shown to be reversible within 72 hours. In view of the absence of effects on the iris and a mean maximum overall score of 1.3 for cornea, it was concluded that the test substance is a category 2 eye irritant.
Studies on skin and eye irritation toxicity are available on DNNSA and BaDNNSA. These studies are indicative of moderate to severe irritation and therefore show that both DNNSA and BaDNNSA are suitable candidates for read-across.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The available studies contain sufficient information to be used for classification and labelling.
Justification for selection of skin irritation / corrosion
endpoint:
Studies were conducted prior to GLP regulations but used methods
generally consistent with accepted procedures. Two studies of equal
quality are available. Both can be indicated as key-study. The results
of both studies are comparable.
Justification for selection of eye irritation endpoint:
Studies were conducted prior to GLP regulations but used methods
generally consistent with accepted procedures. Two studies of equal
quality are available. Both can be indicated as key-study. The results
of both studies are comparable
Effects on skin irritation/corrosion: irritating
Effects on eye irritation: moderately irritating
Justification for classification or non-classification
Based on the outcome of the available tests, the test substance needs to classified as skin irritant (CLP category 2, H315: Causes skin
irritation) and severe eye irritant (CLP category 2, H319: Causes serious eye irritation).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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