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Description of key information

Observations in an acute inhalation toxicity rat study indicate exposure can lead to corneal opacity and eye irritation when exposed to an atmosphere containing the constituent Fluorosulfonyl difluoroacetyl fluoride in a gaseous form.

There are no experimental results related to skin corrosion in a standard test, but in an acute inhalation test performed with the fluorosulphoronyl difluoroacetyl fluoride in a gaseous form, erythema was observed in rats exposed at lethal concentration, and skin oedema has been observed on the ear skin of some rats, which may indicate irritating and/or corrosive effects.

Information from publications on chemical reactivity indicated that both forms (ring sultone and linear form) can react with water to form the acid form 2,2-​difluoro-​2-​(fluorosulfonyl)​acetic acid (CAS1717-59 -5) and hydrogen fluoride.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no study available

Eye irritation

Link to relevant study records
Reference
Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Remarks:
Assessment based on effects reported in acute inhalation study
Reason / purpose:
exposure-related information
Principles of method if other than guideline:
- Principle of test: Standard acute inhalation toxicity.
- Short description of test conditions: 5 groups of 6 rats were exposed to gazeous atmosphere at various concentrations for 4 hours.
- Parameters analysed / observed: lethal effects and clinical signs
GLP compliance:
no
Remarks:
prior to GLP standards
Species:
rat
Strain:
other: ChR:CD
Irritation parameter:
other: Corneal opacity
Remarks on result:
probability of severe irritation
Remarks:
corneal opacity observed in several rats exposed for 4 hours by inhalation
Irritant / corrosive response data:
corneal opacity was observed in several rats exposed for 4 hours by inhalation
Interpretation of results:
Category 1 (irreversible effects on the eye) based on GHS criteria
Conclusions:
Based on corneal opacity observed in several rats exposed for 4 hours by inhalation at lethal concentration of the test material in a gaseous form, and eye redness in animals exposed at non-lethal concentrations, the test material is considered as causing severe eye damage.
Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irreversible damage)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Information from publications on chemical reactivity indicated that both forms (ring sultone and linear form) can react with water to form the acid form 2,2-​difluoro-​2-​(fluorosulfonyl)​acetic acid (CAS 1717 -59 -5) and hydrogen fluoride.

2,2-​difluoro-​2-​(fluorosulfonyl)​acetic acid is reported to behave as a strong acid, and hydrogen fluoride is a known corrosive substance.

Justification for classification or non-classification

There are no experimental results according to standardised methods for skin or eye corrosion/irritation. However; based on the observed effects in the acute inhalation study and on the documented reactivity with water or moisture to form a carboxylic acid and hydrogen fluoride, as a default approach the reaction mass of difluoro(fluorosulphonyl)acetyl fluoride and 3,3,4,4-tetrafluoro-1,2-oxathietane 2,2-dioxide is considered as corrosive to skin, corrosive Subcat.1A, H314 and Eye Damage Cat.1, H318.