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EC number: 947-152-2 | CAS number: -
- Life Cycle description
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- Appearance / physical state / colour
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- Endpoint summary
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- Environmental data
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- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
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- Toxicological Summary
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- Acute Toxicity
- Irritation / corrosion
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Endpoint summary
Administrative data
Description of key information
Observations in an acute inhalation toxicity rat study indicate exposure can lead to corneal opacity and eye irritation when exposed to an atmosphere containing the constituent Fluorosulfonyl difluoroacetyl fluoride in a gaseous form.
There are no experimental results related to skin corrosion in a standard test, but in an acute inhalation test performed with the fluorosulphoronyl difluoroacetyl fluoride in a gaseous form, erythema was observed in rats exposed at lethal concentration, and skin oedema has been observed on the ear skin of some rats, which may indicate irritating and/or corrosive effects.
Information from publications on chemical reactivity indicated that both forms (ring sultone and linear form) can react with water to form the acid form 2,2-difluoro-2-(fluorosulfonyl)acetic acid (CAS1717-59 -5) and hydrogen fluoride.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no study available
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- Assessment based on effects reported in acute inhalation study
- Reason / purpose for cross-reference:
- exposure-related information
- Principles of method if other than guideline:
- - Principle of test:
Standard acute inhalation toxicity.
- Short description of test conditions: 5 groups of 6 rats were exposed to gazeous atmosphere at various concentrations for 4 hours.
- Parameters analysed / observed: lethal effects and clinical signs - GLP compliance:
- no
- Remarks:
- prior to GLP standards
- Species:
- rat
- Strain:
- other: ChR:CD
- Irritation parameter:
- other: Corneal opacity
- Remarks on result:
- probability of severe irritation
- Remarks:
- corneal opacity observed in several rats exposed for 4 hours by inhalation
- Irritant / corrosive response data:
- corneal opacity was observed in several rats exposed for 4 hours by inhalation
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- Based on corneal opacity observed in several rats exposed for 4 hours by inhalation at lethal concentration of the test material in a gaseous form, and eye redness in animals exposed at non-lethal concentrations, the test material is considered as causing severe eye damage.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irreversible damage)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Information from publications on chemical reactivity indicated that both forms (ring sultone and linear form) can react with water to form the acid form 2,2-difluoro-2-(fluorosulfonyl)acetic acid (CAS 1717 -59 -5) and hydrogen fluoride.
2,2-difluoro-2-(fluorosulfonyl)acetic acid is reported to behave as a strong acid, and hydrogen fluoride is a known corrosive substance.
Justification for classification or non-classification
There are no experimental results according to standardised methods for skin or eye corrosion/irritation. However; based on the observed effects in the acute inhalation study and on the documented reactivity with water or moisture to form a carboxylic acid and hydrogen fluoride, as a default approach the reaction mass of difluoro(fluorosulphonyl)acetyl fluoride and 3,3,4,4-tetrafluoro-1,2-oxathietane 2,2-dioxide is considered as corrosive to skin, corrosive Subcat.1A, H314 and Eye Damage Cat.1, H318.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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