difluoro(fluorosulphonyl)acetyl fluoride and 3,3,4,4-tetrafluoro-1,2-oxathietane 2,2-dioxide

Endpoint summary

Description of key information

Observations in an acute inhalation toxicity rat study indicate exposure can lead to corneal opacity and eye irritation when exposed to an atmosphere containing the constituent Fluorosulfonyl difluoroacetyl fluoride in a gaseous form.

There are no experimental results related to skin corrosion in a standard test, but in an acute inhalation test performed with the fluorosulphoronyl difluoroacetyl fluoride in a gaseous form, erythema was observed in rats exposed at lethal concentration, and skin oedema has been observed on the ear skin of some rats, which may indicate irritating and/or corrosive effects.

Information from publications on chemical reactivity indicated that both forms (ring sultone and linear form) can react with water to form the acid form 2,2-​difluoro-​2-​(fluorosulfonyl)​acetic acid (CAS1717-59 -5) and hydrogen fluoride.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion

Endpoint conclusion:

no study available

Eye irritation

Link to relevant study records

Reference

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Remarks:

Assessment based on effects reported in acute inhalation study

Reason / purpose for cross-reference:

exposure-related information

Principles of method if other than guideline:

- Principle of test: Standard acute inhalation toxicity.
- Short description of test conditions: 5 groups of 6 rats were exposed to gazeous atmosphere at various concentrations for 4 hours.
- Parameters analysed / observed: lethal effects and clinical signs

GLP compliance:

no

Remarks:

prior to GLP standards

Species:

rat

Strain:

other: ChR:CD

Irritation parameter:

other: Corneal opacity

Remarks on result:

probability of severe irritation

Remarks:

corneal opacity observed in several rats exposed for 4 hours by inhalation

Irritant / corrosive response data:

corneal opacity was observed in several rats exposed for 4 hours by inhalation

Interpretation of results:

Category 1 (irreversible effects on the eye) based on GHS criteria

Conclusions:

Based on corneal opacity observed in several rats exposed for 4 hours by inhalation at lethal concentration of the test material in a gaseous form, and eye redness in animals exposed at non-lethal concentrations, the test material is considered as causing severe eye damage.

Endpoint conclusion

Endpoint conclusion:

adverse effect observed (irreversible damage)

Respiratory irritation

Endpoint conclusion

Endpoint conclusion:

no study available

Additional information

Information from publications on chemical reactivity indicated that both forms (ring sultone and linear form) can react with water to form the acid form 2,2-​difluoro-​2-​(fluorosulfonyl)​acetic acid (CAS 1717 -59 -5) and hydrogen fluoride.

2,2-​difluoro-​2-​(fluorosulfonyl)​acetic acid is reported to behave as a strong acid, and hydrogen fluoride is a known corrosive substance.

Justification for classification or non-classification

There are no experimental results according to standardised methods for skin or eye corrosion/irritation. However; based on the observed effects in the acute inhalation study and on the documented reactivity with water or moisture to form a carboxylic acid and hydrogen fluoride, as a default approach the reaction mass of difluoro(fluorosulphonyl)acetyl fluoride and 3,3,4,4-tetrafluoro-1,2-oxathietane 2,2-dioxide is considered as corrosive to skin, corrosive Subcat.1A, H314 and Eye Damage Cat.1, H318.