Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 238-339-3 | CAS number: 14367-46-5
Endpoint summary
Administrative data
Description of key information
Adsorption/desorption:
The Soil Adsorption Coefficient i.e Koc value of test substance N-ethyl-1-(4-methoxyphenyl)propan-2-amine(CAS no. 14367 -46 -5) was estimated using Adsorption Coefficient module (v12.1.0.50374) program as Koc 1.0 dimensionless (log Koc= 0.0) at pH range 1-7 and at pH range 8-14 Koc value was estimated to be in range 1.78 - 476 (log Koc= 0.2504 -2.6776). By considering log Koc value of pH 7 which is log Koc =0 indicates that the test substance N-ethyl-1-(4-methoxyphenyl)propan-2-amine has a negligible sorption to soil and therefore has rapid migration potential to groundwater.
Additional information
Adsorption/desorption:
Various predicted data studies for target chemical N-ethyl-1-(4-methoxyphenyl)propan-2-amine (CAS No. 14367-46-5) and experimental study for its structurally similar read across chemical have been reviewed for adsorption endpoint and their results are summarized below.
In first predicted data study the Soil Adsorption Coefficient i.e Koc value of test substance N-ethyl-1-(4-methoxyphenyl)propan-2-amine(CAS no. 14367 -46 -5) was estimated using Adsorption Coefficient module (v12.1.0.50374) program of Advanced Chemistry Development /I-lab predictive module as Koc 1.0 dimensionless (log Koc= 0.0) at pH range 1-7 and at pH range 8-14 Koc value was estimated to be in range 1.78 - 476 (log Koc= 0.2504 -2.6776). By considering log Koc value of pH 7 which is log Koc =0 indicates that the test substanceN-ethyl-1-(4-methoxyphenyl)propan-2-aminehas a negligible sorption to soil and therefore has rapid migration potential to groundwater.
Next study was done by using Sci Finder database the soil adsorption co-efficient i.e., Koc value of test chemical N-ethyl-1-(4-methoxyphenyl)propan-2-amine(CAS no. 14367-46-5) at pH range 1-7 was estimated to be 1.0 dimensionless (log Koc = 0.0) and at pH 8, 9 and 10 Koc value was estimated to be 2.31, 18.2 and 141 dimensionless (Log koc = 0.3636,1.2600, 2.1492) respectively at temperature 25 deg.c. these log Koc values suggest that this test chemical has negligible to slow sorption to soil and sediments and therefore has rapid to moderate migration potential to ground water.
Another prediction was done by Using Chemspider-ACD/Phy chem suite the soil adsorption co-efficient i.e., Koc value of test substance N-ethyl-1-(4-methoxyphenyl)propan-2-amine (CAS no. 14367 -46 -5) was estimated to be 1.0 dimensionless (log Koc= 0) at pH 5.5 and pH 7.4 and temperature 25 deg.C This Koc value at different pH indicates that the chemical N-ethyl-1-(4-methoxyphenyl)propan-2-amine has negligible sorption to soil and sediments and therefore has rapid migration potential to ground water.
Last study was experimental study done by SSS, 2018 in this study the adsorption coefficient Koc in soil and in sewage sludge of test chemical was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 121 for testing of Chemicals. The reference substances were chosen according to structural similarity with the test substance and calibration graph prepared. The reference substances were xylene, ethylbenzene and toluene having Koc value ranging from 2.369 to 2.649. The Log Koc value was found to be 1.15385 ± 0.0029 at 25°C. The results indicate that the test chemical has negligible sorption to soil and sediment and therefore has rapid migration potential to ground water.
By considering results of all the studies mentioned above it can be concluded that log Koc value of test chemical N-ethyl-1-(4-methoxyphenyl)propan-2-amine (CAS No. 14367-46-5)is 0.0 dimensionless. This log koc value indicates that test chemical has negligible sorption to soil and sediment and therefore has rapid migration potential to ground water.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
