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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
14.05. - 23.08.1982
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1982
Report date:
1982

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: "Appraisal of the safety of chemicals in foods, drugs and cosmetics" (Food and Drug Administration)
Principles of method if other than guideline:
"Appraisal of the safety of chemicals in foods, drugs and cosmetics" (Food and Drug Administration)
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Reference substance 001
Cas Number:
83732-72-3
Test material form:
solid
Specific details on test material used for the study:
Analogous test substance

Test animals

Species:
other: rat/mouse
Details on test animals or test system and environmental conditions:
rat: male/female
mouse: female

Conditions:
Air-conditioned with approx. 15 air changes per hour, temperature 20 ± 2°C and relative humidity 50% ± 5%, 12 hours artificial light /12 hours dark.

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Details on oral exposure:
food deprivation priot testing: 16 h
diet/water: ad libitum
Doses:
rat:
10% aqueous solution: 600, 800, 900 mg/kg bw
20% aqueous solution: 700 mg/kg bw

mouse:
5% aqueous solution: 625, 700, 775, 850, 925 mg/kg bw
No. of animals per sex per dose:
mouse (female): 10
rat (male/female): 6
Control animals:
yes
Details on study design:
Observation period: 14 days

Results and discussion

Effect levelsopen allclose all
Key result
Sex:
female
Dose descriptor:
LD50
Effect level:
650 mg/kg bw
Key result
Sex:
male
Dose descriptor:
LD50
Effect level:
700 mg/kg bw
Sex:
female
Dose descriptor:
LD50
Effect level:
813 mg/kg bw

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
The test substance has to be classified as slightly toxic according to Hodge and Sterner.
Executive summary:

The following results were found under the described test conditions:

1. In the examined dosages the test substance leads to the following toxic symptoms:

loss of activity, piloerection, diarrhea and exitus.

2. The LD50 was found to be:

650 mg/kg bw in female Wistar rats

700 mg/kg bw in male Wistar rats

3. The test substance has to be classified as slightly toxic according to Hodge and Sterner.