Registration Dossier
Registration Dossier
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EC number: 215-208-9 | CAS number: 1313-59-3
Endpoint summary
Administrative data
Description of key information
The instantaneous hydrolysis of disodium oxide (Na2O - n°CAS 1313 -59 -3) according the reaction:
Na2O + H2O -> 2NaOH
was confirmed by industrial practice (see section 5.1.2 of the IUCLID dossier). After the reaction, the pH of the solution is > 12. Therefore, disodium oxide is considered as corrosive.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study need not be conducted because the available information indicates that the criteria are met for classification as corrosive to the skin or irritating to eyes
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vitro / ex vivo
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study need not be conducted because the available information indicates that the criteria are met for classification as corrosive to the skin or irritating to eyes
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Justification for classification or non-classification
With the physico-chemical property (sodium hydroxide generation) and the weight of evidence (industrial practise), disodium oxide is considered as corrosive on the criteria basis of the CLP regulation.
It is not possible to assign a sub-category (1A, 1B, 1C) on basis on physico-chemical effects (guidance on the application of the CLP criteria, version 5.0, July 2017).
Thereover, these corrosive sub-categories apply to some authorities and in transport, assigning or changing the packing group is particularly significant as it determines the requirements for the containment system and downstream consequences relating to the transport operation. The relationship between ADR (Agreement on Dangerous goods by Road) classification and GHS corrosive classification has been evaluated by the Committee of Experts on the Transport of Dangerous Goods and on the Globally Harmonized System of classification and Labelling of Chemicals, on 2012 and 2013 (ref. UN/SCETDG/41/ INF.53, UN/SCEGHS/23/INF.18, ST/SG/AC.10/C.3/2013/68 and ST/SG/AC.10/C.4/2013/8)
The committee concluded on the alignment for packing group II (and hazard class 8, the ADR classification for Disodium oxide, n°UN 1825, Class 8) with Skin corrosion Cat 1B.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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